文献詳細
今月の臨床 体外受精治療の行方─問題点と将来展望
体外受精治療の将来展望
文献概要
●卵巣中の卵子は加齢とともに量と質が低下していくと考えられており,質の低下が「卵子老化」といわれている.
●卵子老化の原因としてミトコンドリアの機能低下が推測されているが,現状では治療法や予防法は確立していない.
●卵巣組織中から「卵子幹細胞」ともいえる細胞が分離され,これを用いた生殖補助医療も検討されている.
●卵子老化の原因としてミトコンドリアの機能低下が推測されているが,現状では治療法や予防法は確立していない.
●卵巣組織中から「卵子幹細胞」ともいえる細胞が分離され,これを用いた生殖補助医療も検討されている.
参考文献
1) Selesniemi K, et al : Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies. Proc Natl Acad Sci U S A 108 : 12319─12324, 2011
2) Wu LL, et al : High-fat diet causes lipotoxicity responses in cumulus-oocyte complexes and decreased fertilization rates. Endocrinology 151 : 5438─5445, 2010
3) Nelson SM, et al : The ageing ovary and uterus : new biological insights. Hum Reprod Update 19 : 67─83, 2013
4) Moawad AR, et al : l-carnitine supplementation during vitrification of mouse germinal vesicle stage-oocytes and their subsequent in vitro maturation improves meiotic spindle configuration and mitochondrial distribution in metaphase II oocytes. Hum Reprod 29 : 2256─2268, 2014
5) Bentov Y, Casper RF : The aging oocyte--can mitochondrial function be improved? Fertil Steril 99 : 18─22, 2013
6) Johnson J, et al : Germline stem cells and follicular renewal in the postnatal mammalian ovary. Nature 428 : 145─150, 2004
7) Zou K, et al : Production of offspring from a germline stem cell line derived from neonatal ovaries. Nat Cell Biol 11 : 631─636, 2009
8) White YA, et al : Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women. Nat Med 18 : 413─421, 2012
9) Kagawa N, et al : Successful vitrification of bovine and human ovarian tissue. Reprod Biomed Online 18 : 568─577, 2009
10) Woods DC, Tilly JL : The next(re) generation of ovarian biology and fertility in women : is current science tomorrow’s practice? Fertil Steril 98 : 3─10, 2012
11) Woods DC, Tilly JL : Isolation, characterization and propagation of mitotically active germ cells from adult mouse and human ovaries. Nat Protoc 8 : 966─988, 2013
12) Telfer EE, McLaughlin M : In vitro development of ovarian follicles. Semin Reprod Med 29 : 15─23, 2011
13) Casper RF : Autologous mitochondrial injection to increase energy in oocytes. The 21st World Congress on Controversies in Obstetrics, Gynecology & Infertility(COGI), Guilin, China 2015 : May 7─10.(http://www.ovascience.com/files/COGI_Casper_May_2015.pdf)
14) Hayashi K, et al : Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice. Science 338 : 971─975, 2012
15) Nakaki F, et al : Induction of mouse germ-cell fate by transcription factors in vitro. Nature 501 : 222─226, 2013
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