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臨床婦人科産科70巻1号

2016年01月発行

文献概要

合併増大号 今月の臨床 難治性の周産期common diseaseへの挑戦 反復後期流・早産の治療

既往早産妊婦の管理─⑤乳酸菌療法

著者: 永松健1 藤井知行1

所属機関: 1東京大学産科婦人科学教室

ページ範囲:P.31 - P.35

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●妊婦の腟内細菌叢の異常が早産のリスク因子となっている.

●網羅的解析技術の進歩により腟内細菌叢の全貌が解明されつつある.

Lactobacillusのもつ複数の特異的機能が子宮内感染の防御にかかわっている.

●プロバイオティクスの応用は早産抑止のための有望な治療戦略である.

参考文献

1) Gardella C, et al : Identification and sequencing of bacterial rDNAs in culture-negative amniotic fluid from women in premature labor. Am J Perinatol 21 : 319─323, 2004
2) Ercan E, et al : Evaluation of periodontal pathogens in amniotic fluid and the role of periodontal disease in pre-term birth and low birth weight. Acta Odontol Scand 71 : 553─559, 2013
3) Donders GG, et al : Predictive value for preterm birth of abnormal vaginal flora, bacterial vaginosis and aerobic vaginitis during the first trimester of pregnancy. BJOG 116 : 1315─1324, 2009
4) Romero R, et al : The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women. Microbiome 2 : 4, 2014
5) Kaur B, et al : Biomedical applications of fermenticin HV6b isolated from Lactobacillus fermentum HV6b MTCC10770. Biomed Res Int 2013 : 168438, 2013
6) Donia MS, et al : A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics. Cell 158 : 1402─1414, 2014
7) McMillan A, et al : Adhesion of Lactobacillus iners AB-1 to human fibronectin : a key mediator for persistence in the vagina? Reprod Sci 20 : 791─796, 2013
8) Rose WA, et al : Commensal bacteria modulate innate immune responses of vaginal epithelial cell multilayer cultures. PloS one 7 : e32728, 2012
9) Wagner RD, et al : Probiotic lactobacillus and estrogen effects on vaginal epithelial gene expression responses to Candida albicans. J Biomed Sci 19 : 58, 2012
10) Elawadli I, et al : Differential effects of lactobacilli on activation and maturation of mouse dendritic cells. Benef Microbes 5 : 323─334, 2014
11) Witkin SS, et al : Lactic acid stimulates interleukin-23 production by peripheral blood mononuclear cells exposed to bacterial lipopolysaccharide. FEMS Immunol Med Microbiol 61 : 153─158, 2011
12) Hoyme UB, et al : Efficient prematurity prevention is possible by pH-self measurement and immediate therapy of threatening ascending infection. Eur J Obstet Gynecol Reprod Biol 115 : 148─153, 2004
13) Brocklehurst P, et al : Antibiotics for treating bacterial vaginosis in pregnancy. The Cochrane Database Syst Rev (1) : CD000262, 2013
14) Petrova MI, et al : Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health. Front Physiol 6 : 81, 2015
15) Witkin SS, et al : Influence of vaginal bacteria and D- and L-lactic acid isomers on vaginal extracellular matrix metalloproteinase inducer : implications for protection against upper genital tract infections. MBio 4 : e00460─13, 2013
16) Tomusiak A, et al : Efficacy and safety of a vaginal medicinal product containing three strains of probiotic bacteria : a multicenter, randomized, double-blind, and placebo-controlled trial. Drug Des Devel Ther 9 : 5345─5354, 2015
17) Yang S, et al : Is there a role for probiotics in the prevention of preterm birth? Front Immunol 6 : 62, 2015
18) Elias J, et al : Are probiotics safe for use during pregnancy and lactation? Can Fam Physician 57 : 299─301, 2011
19) Dugoua JJ, et al : Probiotic safety in pregnancy : a systematic review and meta-analysis of randomized controlled trials of Lactobacillus, Bifidobacterium, and Saccharomyces spp. J Obstet Gynaecol Can 31 : 542─552, 2009

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1294

印刷版ISSN:0386-9865

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