臨床婦人科産科70巻10号

2016年10月発行

今月の臨床 胎児発育不全（FGR）の管理Up To Date 病態の最新知見

FGRにおける胎児行動の変化と評価

著者： 諸隈誠一¹ 前原佳奈² 大川彦宏² 加藤聖子²

所属機関： ¹九州大学環境発達医学研究センター ²九州大学大学院医学研究院生殖病態生理学

ページ範囲：P.894 - P.898

●胎児の行動は中枢神経機能の表現系ととらえることができる．

●FGRにおける胎児行動について概説する．

●FGRの眼球運動に関する予備研究について紹介する．

参考文献

1）Blair EM, et al : Fetal growth restriction and risk of cerebral palsy in singletons born after at least 35 weeks' gestation. Am J Obstet Gynecol 212 : 520. e1─7, 2015

2）Jelliffe-Pawlowski LL, et al : Neurodevelopmental outcome at 8 months and 4 years among infants born full-term small-for-gestational-age. J Perinatol 24 : 505─514, 2004

3）Tolsa CB, et al : Early alteration of structural and functional brain development in premature infants born with intrauterine growth restriction. Pediatr Res 56 : 132─138, 2004

4）Thompson DK, et al : Perinatal risk factors altering regional brain structure in the preterm infant. Brain 130 : 667─677, 2007

5）Lodygensky GA, et al : Intrauterine growth restriction affects the preterm infant's hippocampus. Pediatr Res 63 : 438─443, 2008

6）Bekedam D, et al : Motor behaviour in the growth retarded fetus. Early Hum Dev 12 : 155─165, 1985

7）Prechtl HF, et al : An early marker for neurological deficits after perinatal brain lesions. Lancet 349 : 1361─1363, 1997

8）Sival DA, et al : The relationship between the quantity and quality of prenatal movements in pregnancies complicated by intra-uterine growth retardation and premature rupture of the membranes. Early Hum Dev 30 : 193─209, 1992

9）Sival DA, et al : The effect of intrauterine growth retardation on the quality of general movements in the human fetus. Early Hum Dev 28 : 119─132, 1992

10）Nijhuis JG, et al : Are there behavioural states in the human fetus? Early Hum Dev 6 : 177─195, 1982

11）Prechtl HF, et al : Is neurological assessment of the fetus possible? Eur J Obstet Gynecol Reprod Biol 75 : 81─84, 1997

12）Prechtl HFR, et al : Organization of physiological parameters in normal and neurological abnormal infants. Neuropaediatrie 1 : 101─129, 1969

13）Abreu-Villaça Y, et al : Developmental aspects of the cholinergic system. Behav Brain Res 221 : 367─378, 2011

14）Miyamoto H, et al : Experience-dependent slow-wave sleep development. Nat Neurosci 6 : 553─554, 2003

15）Greene G, et al : Childhood sleeping difficulties and depression in adulthood : the 1970 British Cohort Study. J Sleep Res 24 : 19─23, 2015

16）Mirmiran M, et al : Suppression of active sleep by chronic treatment with chlorimipramine during early postnatal development : effects upon adult sleep and behavior in the rat. Brain Res 204 : 129─146, 1981

17）Mirmiran M, et al : Pharmacological suppression of REM sleep prior to weaning counteracts the effectiveness of subsequent environmental enrichment on cortical growth in rats. Brain Res 283 : 102─105, 1983

18）Mirmiran M, et al : Effects of experimental suppression of active（REM）sleep during early development upon adult brain and behavior in the rat. Brain Res 283 : 277─286, 1983

19）Mirmiran M, et al : Development of fetal and neonatal sleep and circadian rhythms. Sleep Med Rev 7 : 321─334, 2003

20）Feinberg I : Eye movement ativity during sleep and intellectual function in mental retardation. Science 159 : 1256, 1968

21）Hashimoto T, et al : Sleep Polygraphic Study of Infantile Spasms ; Rapid Eye Movements during REM Sleep. Brain Dev 10 : 297─302, 1978

22）Tanguay PE, et al : Rapid eye movement（REM）activity in normal and autistic children during REM sleep. J Autism Child Schizophr 6 : 275─288, 1976

23）Limoges E, et al : Atypical sleep architecture and the autism phenotype. Brain 128 : 1049─1061, 2005

24）Richdale AL, et al : Sleep problems in autism spectrum disorders : prevalence, nature, ＆possible biopsychosocial aetiologies. Sleep Med Rev 13 : 403─411, 2009

25）Arditi-Babchuk H, et al : Rapid eye movement（REM） in premature neonates and developmental outcome at 6 months. Infant Behav Dev 32 : 27─32, 2009

26）Birnholz JC : The development of human fetal eye movement patterns. Science 213 : 679─681, 1981

27）Inoue M, et al : Functional development of human eye movement in utero assessed quantitatively with real-time ultrasound. Am J Obstet Gynecol 155 : 170─174, 1986