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臨床婦人科産科70巻4号

2016年04月発行

文献概要

増刊号 ─知りたい最新情報がすぐわかる!─不妊・不育症診療パーフェクトガイド 6.生殖補助医療

黄体補充療法の種類と特徴

著者: 藤原敏博1

所属機関: 1順和会山王病院リプロダクション・婦人科内視鏡治療センター

ページ範囲:P.247 - P.252

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◉ARTにおいては,黄体機能が損なわれるかあるいは内因性の黄体機能が全く存在しないため,黄体補充療法は必須である.
◉黄体補充療法に用いるエストロゲンやプロゲステロンは天然型が好ましい.
◉黄体補充療法に用いるプロゲステロンは安全性・有効性・利便性の面から,天然型プロゲステロン腟剤が推奨される.

参考文献

1)Practice Committee of the American Society for Reproductive Medicine : The clinical relevance of luteal phase deficiency : a committee opinion. Fertil Steril 98 : 1112─1117, 2012
2)Lutjen T, et al : The establishment and maintenance of pregnancy using in vitro fertilization and embryo donation in a patient with primary ovarian failure. Nature 307 : 174─175, 1984
3)Hurd WW, et al : Luteal support with both estradiol and progesterone after clomiphene citrate stimulation for in vitro fertilization. Fertil Steril 66 : 587─592, 1996
4)Keenan JA, et al : Luteal phase support with hCG does not improve fecundity rate in human menopausal gonadotropin-stimulated cycles. Obstet Gynecol 79 : 983─987, 1992
5)Tavaniotou A, et al : Ovulation induction disrupts luteal phase function. Ann N Y Acad Sci 943 : 55─63, 2001
6)Beckers NG, et al : Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone(GnRH) agonist to induce final oocyte maturation in in vitro fertilization patients after ovarian stimulation with recombinant follicle-stimulating hormone and GnRH antagonist cotreatment. J Clin Endocrinol Metab 88 : 4186─4192, 2003
7)Stovall DW, et al : Selective early elimination of luteal support in assisted reproduction cycles using a gonadotropin-releasing hormone agonist during ovarian stimulation. Fertil Steril 70 : 1056─1062, 1998
8)Buvat J, et al : Luteal support after luteinizing hormone-releasing hormone agonist for in vitro fertilization : superiority of human chorionic gonadotropin over oral progesterone. Fertil Steril 53 : 490─494, 1990
9)Fatemi HM, et al : An update of luteal phase support in stimulated IVF cycles. Hum Reprod Update 13 : 581─590, 2007
10)Van der Linden M, et al : Luteal phase support for assisted reproduction cycles. Cochrane Database of Systematic Reviews 2011, Issue 10.Art.No. : CD009154.(DOI : 10.1002/14651858.CD009154.pub2)
11)Pirard C, et al : GnRH agonist as luteal phase support in assisted reproduction technique cycles : results of a pilot study. Hum Reprod 21 : 1894─1900, 2006
12)東口篤司 : 国内のARTにおけるホルモン補充を考える.日受精着床会誌31 : 231─235, 2014
13)Vaisbuch E, et al : Reprod Biomed Online 28(3) : 330─335, 2014
14)東口篤司 : ARTにおけるホルモン補充の現状─日本IVF学会によるアンケート調査の結果.日本IVF学会雑誌17 : 25─33, 2014
15)The Practice Committee of the he American Society for Reproductive Medicine : Progesterone supplementation during the luteal phase and early pregnancy in the treatment of infertility : an educational bulletin. Fertil Steril 89 : 789─792, 2008
16)Fujiwara T : A multi-center, randomized, open-label, parallel group study of a natural micronized progesterone vaginal tablet as a luteal support agent in Japanese women ubdergoing assisted reproductive technology : Reprod Med Biol 14 : 185─193, 2015
17)Mochtar MH,et al : Timing luteal phase support in GnRH agonist down-regulated IVF/embryo transfer cycles. Hum Reprod 21 : 905─908, 2006
18)Williams SC, et al : Delaying the initiation of progesterone supplementation results in decreased pregnancy rates after in vitro fertilization : a randomaized, prospective study. Fertil Steril 76 : 1140─1143, 2001
19)Nyboe Andersen A, et al : Progesterone supplementation during early gestations after IVF or ICSI has no effect on the delivery rates : a randomized controlled trial. Hum Reprod 17 : 357─361, 2002
20)Banz C, Katalinic A, et al : Preparation of cycles for cryopreservation transfers using estradiol patches and Crinone 8%vaginal gel is effective and does not need any monitoring. Eur J Obstet Gynecol Reprod Biol 103 : 43─47, 2002
21)Cicinelli E, et al : Transvaginal progesterone : evidence for a new functional‘portal system’flowing from the vagina to the uterus. Human Reprod Update 5 : 365─372, 1999
22)Yanushpolsky EH : Luteal support in in vitro fertilization. Semin Reprod Med 33 : 118─127, 2015

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1294

印刷版ISSN:0386-9865

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