臨床婦人科産科70巻4号

2016年04月発行

増刊号 ─知りたい最新情報がすぐわかる！─不妊・不育症診療パーフェクトガイド

6．生殖補助医療

Q8　アシストハッチング法のデメリットについて教えてください

著者： 矢野浩史¹ 久保敏子¹

所属機関： ¹矢野産婦人科IVFセンター

ページ範囲：P.287 - P.287

文献概要

A　アシストハッチング（AH）法はすべての症例に有効というわけではありません．また，AH法による一卵性双胎や先天性奇形の発生リスクや胚にダメージを与えるリスクがあります．

参考文献

1）Martins WP, et al : Assisted hatching of human embryos : a systematic review and meta-analysis of randomized controlled trials. Hum Reprod Update 17 : 438─453, 2011

2）Practice Committee of the American Society for Reproductive Medicine ; Practice Committee of the Society for Assisted Reproductive Technology : Role of assisted hatching in invitro fertilization : a guideline. Fertil Steril 102 : 348─351, 2014

3）Nakasuji T, et al : Validity for assisted hatching on pregnancy rate in assisted reproductive technology : analysis based on results of Japan Assisted Reproductive Technology Registry System 2010. J Obstet Gynaecol Res 40 : 1653─1660, 2014

4）Bulmer MG : The Biology of twinning in man. Clarendon Press, Oxford, 1970

5）Vitthala S, et al : The risk of monzygotic twins after assisted reproductive technology : a systematic review and meta-analysis. Hum Reprod Update 15 : 45─55, 2009

6）Schieve LA, et al : Does assisted hatching pose a risk for monozygotic twinning in pregnancies conceived through in vitro fertilization? Fertil Steril 74 : 288─294, 2000

7）Milki AA, et al : Incidence of monozygotic twinning with blastocyst transfer compared to cleavage-stage transfer. Ferti Steril 79 : 503─506, 2003

8）Jwa J, et al : Risk of major congenital anomalies after assisted hatching : analysis of three-year data from the national assisted reproduction registry in Japan. Fertil Steril 104 : 71─78, 2015