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臨床婦人科産科70巻5号

2016年05月発行

今月の臨床 糖尿病が女性ヘルスケア・がんに与えるリスク

糖尿病と婦人科がん

糖尿病が卵巣がんの病態・予後に与えるリスク

著者: 平田幸広1 矢内原臨1 岡本愛光1

所属機関: 1東京慈恵会医科大学産婦人科

ページ範囲:P.411 - P.416

文献概要

●本稿では,「糖尿病が発がんに関与するさまざまなメカニズム」「糖尿病が卵巣がんの発生および予後に与える影響」「糖尿病治療薬であるメトホルミンの抗腫瘍効果」について解説する.

参考文献

1)International Diabetes Federation : IDF Diabetes Atlas[article online], 4th ed. Brussels, Belgium, 2009
2)Seiden MV : Gynecologic malignancies. Harrison's principles of internal medicine(18th ed)(Longo DL, et al eds)McGraw-Hill, 2012
3)Engels CC, et al : The influence of insulin-like growth factor-1-receptor expression and endocrine treatment on clinical outcome of postmenopausal hormone receptor positive breast cancer patients : a Dutch TEAM substudy analysis. Mol Oncol, 2015[Epub ahead of print]
4)Calle EE, et al : Overweight, obesity and cancer : epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4 : 579─591, 2004
5)Kaaks R : Nutrition, hormones, and breast cancer : Is insulin the missing link? Cancer Causes Control 7 : 605─625, 1996
6)Khandwala HM, et al : The effects of insulin-like growth factors on tumorigenesis and neoplastic growth. Endocr Rev 21 : 215─244, 2000
7)Kluge A, et al : Insulin-like growth factor I is involved in inflammation linked angiogenic processes after microembolisation in porcine heart. Cardiovasc Res 29 : 407─415, 1995
8)Cant JP : IGF-1 stimulates protein synthesis by enhanced signaling through mTORC1 in bovine mammary epithelial cells. Domest Anim Endocrinol 38 : 211─221, 2010
9)Feng Z, et al : The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein. Trends Cell Biol 20 : 427─434, 2010
10)Polak M : Insulin and insulin-like growth factor signaling in neoplasia. Nat Rev Cancer 8 : 915─928, 2008
11)Abdel-Hamid NM, et al : Cytokines as important playmakers of experimental hep-atocarcinogenesis confounded by diabetes. Ann Hepatol 11 : 118─127, 2012
12)Zhong Y, et al : Activation of endoplasmic reticulum stress by hyperglycemia is essential for muller cell-derived inflammatory cytokine production in diabetes. Diabetes 61 : 492─504, 2012
13)de Heredia FP, et al : Obesity, inflammation and the immune system. Proc Nutr Soc 71 : 332─338, 2012
14)Bondia-Pons I, et al : Oxidative stress and inflammation interactions in human obesity. J Physiol Biochem 68 : 701─711, 2012
15)Yamauchi T, et al : Adiponectin receptor as a key player in healthy longevity and obesity related diseases. Cell Metab 17 : 185─196, 2013
16)Villarreal-Molina MT, et al : Adiponectin : anti-inflammatory and cardioprotective effects. Biochimie 94 : 2143─2149, 2012
17)Park J, et al : Leptin and cancer : from cancer stem cells to metastasis. Endocr Relat Cancer 18 : C25─29, 2011
18)Yamaki Kohji : Adipokines. Jpn Soc Food Sci Technol 57 : 319, 2010
19)Collaborative Group on Epidemiological Studies of Ovarian Cancer : Ovarian cancer and oral contraceptives : collaborative reanalysis of data from 45 epidemiological studies including 23 257 women with ovarian cancer and 87 303 controls. Lancet 371 : 303─314, 2008
20)森  満 : リスク要因を解明するための卵巣癌の症例対象研究.日産婦誌48 : 875, 1996
21)Olsen CM, et al : Whiteman DC, et al : Obesity and risk of ovarian cancer subtypes : evidence from the Ovarian Cancer Association Consortium. Endocr Relat Cancer 20 : 251─262, 2013
22)Parazzini F, et al : Ovarian cancer risk and history of selected medical conditions linked with female hormones. Eur J Cancer 33 : 1634─1637, 1997
23)Weiderpass E, et al : Diabetes mellitus and ovarian cancer. Cancer Causes Control 13 : 759─764, 2002
24)Hemminki K, et al : Risk of cancer following hospitalization for type 2 diabetes. Oncologist 15 : 548─555, 2010
25)Shah MM, et al : Diabetes mellitus and ovarian cancer : more complex than just increasing risk. Gynecol Oncol 135 : 273─277, 2014
26)能登 洋,他 : メトホルミンによる癌の予防効果 : メタアナリシスによる検証.第61回日本体質医学会総会,2011
27)Imai A, et al : Clinical benefits of metformin in gynecologic oncology. Oncol Lett 10 : 577─582, 2015
28)Kumar S, et al : Metformin intake is associated with better survival in ovarian cancer : a case-control study. Cancer 119 : 555─562, 2013
29)Patel S, et al : Metformin and epithelial ovarian cancer therapeutics. Cell Oncol(Dordr) 38 : 365─375, 2015
30)Zhang R, et al : Inhibitory effects of metformin at low concentration on epithelial-mesenchymal transition of CD44(+)CD117(+)ovarian cancer stem cells. Stem Cell Res Ther 6 : 262, 2015

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1294

印刷版ISSN:0386-9865

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