臨床婦人科産科70巻5号

2016年05月発行

今月の臨床 糖尿病が女性ヘルスケア・がんに与えるリスク

最近の話題

メトホルミンの抗がん作用

著者： 清野学¹ 太田剛¹ 永瀬智¹

所属機関： ¹山形大学産科婦人科学講座

ページ範囲：P.423 - P.427

文献概要

●メトホルミンはビグアナイド系に分類される血糖降下薬である．肺がんや卵巣がんだけでなく多くのがん種でメトホルミンの効果が示されている．

●メトホルミンはAMPK（adenosine monophosphate-activated protein kinase）を間接的に活性化させることで抗腫瘍効果を示す．

●がんの治療抵抗性としてがん幹細胞という概念があるが，メトホルミンはがん幹細胞を抑制する．

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