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雑誌文献

臨床婦人科産科70巻8号

2016年08月発行

今月の臨床 婦人科悪性腫瘍規約改訂のポイントと対応─「何が」「なぜ」「どのように」変わったのか

子宮体部病変

間葉系腫瘍・癌肉腫の治療と管理

著者: 笠松由佳1 安部正和1 平嶋泰之1

所属機関: 1静岡県立静岡がんセンター婦人科

ページ範囲:P.719 - P.724

文献概要

●根治治療可能な子宮癌肉腫の初回治療は手術であり,腹式子宮全摘術+両側付属器摘出術に加え,骨盤・傍大動脈リンパ節郭清,大網切除を行うことが推奨される.

●完全切除例に対しても術後補助療法が推奨されるが,エビデンスの高い標準治療は確立していない.

●進行再発例には,治療効果,安全性の点からPTX+CBDCA療法の有効性が示唆されている.

参考文献

1)Arend R, et al : Uterine carcinosarcoma. Curr Opin Oncol 23 : 531─536, 2011
2)日本婦人科腫瘍学会 編 : 子宮体がん治療ガイドライン.pp160─169,金原出版,2013
3)Wada H, et al : Molecular evidence that most but not all carcinosarcoma of the uterus are combination tumors. Cancer Res 57 : 5379─5385, 1997
4)The National Comprehensive Cancer Network(NCCN)clinical practice guidelines in oncology. Uterine neoplasm, Version3, 2012 http://www.nccn.org/professionals/physicians_gls/pdf/uterine.pdf
5)Meredith RF, et al : An excess of uterine sarcomas after pelvic irradiation. Cancer 58 : 2003─2007, 1986
6)Sartori E, et al : Carcinosarcoma of the uterus. Gynecol Oncol 67 : 70─75, 1997
7)Callister M, et al : Malignant mixed Mullerian tumors of the uterus : analysis of patterns of failure, prognostic factors, and treatment outcome. Int J Radiat Oncol Biol Phys 58 : 786─796, 2004
8)Sah SH, et al : Uterine sarcomas : then and now. AJR Am J Roentgenol 199 : 213─223, 2012
9)Temkin SM, et al : Early-stage carcinosarcoma of the uterus : the significance of lymph node count. Int J Gynecol Cancer 17 : 215─219, 2007
10)Gadducci A, et al : The management of patients with uterine sarcoma : a debated clinical challenge. Crin Rev Oncol Hematol 65 : 129─142, 2008
11)Nemani D, et al : Assessing the effects of lymphadenectomy and radiation therapy in patients with uterine carcinosarcoma : A SEER analysis. Gynecol Oncol 111 : 82─88, 2008
12)Harano K, et al : Prognostic factors in patients with carcinosarcoma : a multi-institutinal retrospective study from Japanese gynecologic oncology group. Int J Clin Oncol 21 : 168─176, 2016
13)Vrzic-Petronijevic S, et al : Diagnosis and surgical therapy of uterine sarcoma. Acta Chir Iugosl 53 : 67─72, 2006
14)Omura GA, et al : A randomized clinical trial of adjuvant adriamycin in uterine sarcomas : a gynecologic oncology group study. J Clin Oncol 3 : 1240─1245, 1996
15)Sutton GP, et al : Adjuvant ifosfamide and cisplatin in patients with completely resected stage I or II carcinosarcomas(mixed mesodermal tumors) of the uterus : a gynecologic oncology group study. Gynecol Oncol 96 : 630─634, 2005
16)Wolfson AH, et al : A gynecologic oncology group randomized phase III trial of whole abdominal irradiation(WAI) vs. cisplatin-ifosfamide and mesna(CIM)as post-surgical therapy in stage I-IV carcinosarcoma(CS) of the uterus. Gynecol Oncol 107 : 177─185, 2007
17)Otsuki A, et al : Paclitaxel and carboplatin in patients with completely or optimally resected carcinosarcoma of the uterus. a phase II trial by the Japanese uterine sarcoma group and the Tohoku gynecologic cancer unit. Int J Gynecol Cancer 25 : 92─97, 2015
18)Sutton GP, et al : Phase III trial of ifosfamide and mesna in mixed mesodermal tumors of the uterus(a gynecologic oncology group study). J Obstet Gynecol 161 : 309─312, 1989
19)Curtin JP, et al : Paclitaxel in the treatment of carcinosarcoma of the uterus : a gynecologic oncology group study. Gynecol Oncol 83 : 268─270, 2001
20)Thigpen JT, et al : Phase II trial of cisplatin as first-Line chemotherapy in patients with advanced or recurrent uterine sarcomas : a gynecologic oncology group study. J Clin Oncol 9 : 1962─1966, 1991
21)Sutton GP, et al : A phase III trial of ifosfamide with or without cisplatin in carcinosarcoma of the uterus. Gynecol Oncol 79 : 147─153, 2000
22)Homesley HD, et al : Phase III trial of ifosfamide with or without paclitaxel in advanced uterine carcinosarcoma : a gynecologic oncology group study. J Clin Oncol 25 : 526─531, 2007
23)Hoskins PJ, et al : Carboplatin plus paclitaxel for advanced or recurrent uterine malignant mixed mullerian tumors. The British Columbia Cancer Agency experience. Gynecol Oncol 108 : 58─62, 2008
24)Powell MA, et al : Phase II evaluation of paclitaxel and carboplatin in the treatment of carcinosarcoma of the uterus : a gynecologic oncology group study. J Clin Oncol 28 : 2727─2731, 2010
25)Wright JD, et al : The role of radiation in improving survival for early-stage carcinosarcoma and leiomyosarcoma. Am J Obstet Gynecol 199 : 536, 2008
26)Sampath S, et al : The role of adjuvant radiation in uterine sarcomas. Int J Radiat Oncol Biol Phys 76 : 728─734, 2010
27)Leigh A, et al : Uterine carcinosarcoma : a review of the literature. Gynecol Oncol 137 : 581─588, 2015

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1294

印刷版ISSN:0386-9865

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