臨床婦人科産科70巻9号

2016年09月発行

今月の臨床 卵管は脇役か？─その生理と病態

卵管の生理

卵の取り込みと受精卵の輸送

著者： 石東博¹² 小松紘司³ 藤森俊彦¹

所属機関： ¹基礎生物学研究所初期発生研究部門 ²COS Heidelberg，ハイデルベルグ大学 ³愛知医科大学医学部生理学講座

ページ範囲：P.810 - P.816

文献概要

●卵管上皮の繊毛細胞は平面内細胞極性を持しており，卵巣─子宮軸に沿った一方向の繊毛運動を行う．この方向性をもった繊毛運動は卵を膨大部まで運ぶのに十分である．

●繊毛運動のほかにも，卵管の蠕動運動が卵の動きに影響を与える．卵巣─子宮軸に沿って並ぶ上皮ヒダなどの卵管の構造も卵の輸送にかかわる可能性がある．

●卵輸送以外にも，卵管が初期胚の発生において役割を果たすことが報告されてきており，その働きの多くはまだ十分に解明されていない．

参考文献

1）Stewart CA, et al : Mouse oviduct development. Results Probl Cell Differ 55 : 247─262, 2012

2）Agduhr E : Studies on the structure and development of the bursa ovarica and the tuba uterina in the mouse. Acta Zool 8 : 1─133, 1927

3）Behringer R, et al : Manipulating the mouse embryo. Cold Spring Harbor Laboratory Press, 2014

4）Lyons RA, et al : The reproductive significance of human Fallopian tube cilia. Hum Reprod Update 12 : 363─372, 2006

5）Yamanouchi H, et al : Reconstruction of oviduct and demonstration of epithelial fate determination in mice. Biol Reprod 82 : 528─533, 2010

6）Shi D, et al : Celsr1 is required for the generation of polarity at multiple levels of the mouse oviduct. Development 141 : 4558─4568, 2014

7）Bylander A, et al : Rapid effects of progesterone on ciliary beat frequency in the mouse fallopian tube. Reprod Biol Endocrinol 8 : 48, 2010

8）Shi D, et al : Analysis of ciliary beat frequency and ovum transport ability in the mouse oviduct. Genes Cells 16 : 282─290, 2011

9）Afzelius BA, et al : On the function of cilia in the female reproductive tract. Fertil Steril 29 : 72─74, 1978

10）McComb P, et al : The oviductal cilia and Kartagener's syndrome. Fertil Steril 46 : 412─416, 1986

11）Halbert SA, et al : Function and structure of cilia in the fallopian tube of an infertile woman with Kartagener's syndrome. Hum Reprod 12 : 55─58, 1997

12）Halbert SA, et al : Ovum transport in the rat oviductal ampulla in the absence of muscle contractility. Biol Reprod 40 : 1131─1136, 1989

13）Halbert SA, et al : Egg transport in the rabbit oviduct : the roles of cilia and muscle. Science 191 : 1052─1053, 1976

14）Blandau RJ : The mammalian oviduct comparative biology and methodology（Hafez ESE, et al eds）. pp129─162, University of Chicago Press, 1969

15）Koyama H, et al : Mechanical regulation of three-dimensional epithelial fold pattern formation in the mouse oviduct. Biophys J 111, in press（2016）

16）Bakst MR : Structure of the avian oviduct with emphasis on sperm storage in poultry. Exp Zool 282 : 618─626, 1998

17）Wake MH, et al : Oviduct structure and function and reproductive modes in amphibians. J Exp Zool 282 : 477─506, 1998

18）富永彬生 : ハムスター卵管上皮の形態．愛媛県立医療技術大学紀要7 : 5─12, 2010

19）Fernández-Gonzalez R, et al : Suboptimal in vitro culture conditions : an epigenetic origin of long-term health effects. Mol Reprod Dev 74 : 1149─1156, 2007

20）Avilés M, et al : Oviductal secretions : will they be key factors for the future ARTs? Mol Hum Reprod 16 : 896─906, 2010

21）Buhi WC, et al : Secreted proteins of the oviduct. Cells Tissues Organs 166 : 165─179, 2000

22）Ménézo Y, et al : The oviduct : A neglected organ due for re-assessment in IVF. Reprod Biomed Online 30 : 233─240, 2015

23）Matsuura K, et al : Improved development of mouse and human embryos using a tilting embryo culture system. Reprod Biomed Online 20 : 358─364, 2010

24）La Spina FA, et al : Mouse sperm begin to undergo acrosomal exocytosis in the upper isthmus of the oviduct. Dev Biol 411 : 172─182, 2016

25）Yamaguchi R, et al : Disruption of ADAM3 impairs the migration of sperm into oviduct in mouse. Biol Reprod 81 : 142─146, 2009