臨床婦人科産科71巻1号

2017年01月発行

合併増大号　今月の臨床 性ステロイドホルモン研究の最前線と臨床応用 臨床各論 : 使い方の実際

子宮内膜異型増殖症

著者： 牛嶋公生¹

所属機関： ¹久留米大学産科婦人科学講座

ページ範囲：P.101 - P.103

●子宮内膜異型増殖症に対する治療の原則は子宮摘出である．

●保存的治療を計画するのは，その後の妊娠が可能な場合であり，全面搔爬の材料から病理診断された症例に限られる．

●再発率が高いので，いったん病巣が消失した後も，積極的不妊治療や厳重な観察が必要である．

参考文献

1）Zaino RC, et al : Tumors of the uterine corpus : epithelial tumours and precursors. WHO classifications of tumours of female reproductive organs. 4th ed（Kurman RJ, et al eds）. pp125─126, WHO Press, Lyon, 2014

2）Antonsen SL, et al : Patients with atypical hyperplasia of the endometrium should be treated in oncological centers. Gynecol Oncol 125 : 124─128, 2012

3）Gallos ID, et al : Oral progestogens vs levonorgestrel-releasing intrauterine system for endometrial hyperplasia : a systematic review and metaanalysis. Am J Obstet Gynecol 203 : 547. e1─10, 2010

4）Ushijima K, et al : Multicenter phase II study of fertility-sparing treatment with medrxypogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women. J Clin Oncol 25 : 2798─2803, 2007

5）Wheeleer DT, et al : Histologic alterations in endometrial hyperplasia and well-differentiated carcinoma treated with progestins. Am J Surg Pathol 31 : 988─998, 2007

6）Koskas M, et al : Prognostic factors of oncologic and reproductive outcomes in fertility-sparing management of endometrial atypical hyperplasia and adenocarcinoma : systematic review and meta-analysis. Fertile Sterile 101 : 785─794, 2014

7）Gallos ID, et al : Oral progestogens vs levonorgestel-releasing intrauterine system for endometrial hyperplasia. A systematic review and metaanalysis. Am J Obstet Gynecol 203 : 547, e1─10, 2010

8）Park JY, et al : Long-term oncologic outcomes after fertility-sparing management using oral progestin for young women with endometrial cancer（KGOG 2002）. Eur J Cancer 49 : 868─874, 2013

9）Ichinose M, et al : The influence of infertility treatment on the prognosis of endometrial cancer and atypical complex endometrial hyperplasia. Int J Gynecol Cancer 23 : 288─293, 2013

10）Elizur S, et al : Outcome of in vitro fertililzation treatment in infertile women conservatively treated for the endometrial adenocarcinoma. Fertile Sterile 88 : 1562─1567, 2007