臨床婦人科産科71巻5号

2017年05月発行

今月の臨床 万能幹細胞・幹細胞とゲノム編集─再生医療の進歩が医療を変える 産婦人科領域における再生医療とゲノム編集

子宮筋幹細胞の臨床的意義

著者： 小野政徳¹² 丸山哲夫² 田中守²

所属機関： ¹金沢大学医薬保健学域医学系分子移植学産科婦人科 ²慶應義塾大学医学部産婦人科

ページ範囲：P.459 - P.463

●子宮は妊娠ごとに平滑筋細胞の増殖と肥大により著明な増大を示す．

●妊娠子宮におけるダイナミックな変化は生殖年齢を過ぎても人工的に再現することができる．

●このような子宮の高い再生能力は，子宮における幹細胞システムの存在を示唆している．

●単一細胞由来（モノクローナル）と考えられている子宮筋腫の発生起源に幹細胞が関与している．

参考文献

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6）Mas A, et al : Stro-1/CD44 as putative human myometrial and fibroid stem cell markers. Fertil Steril 104 : 225─234, 2015

7）Ono M, et al : CD34 and CD49f double-positive and lineage marker-negative cells isolated from human myometrium exhibit stem cell-like properties involved in pregnancy-induced uterine remodeling. Biol Reprod 93 : 37, 2015

8）Makinen N, et al : MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas. Science 334 : 252─255, 2011

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