臨床婦人科産科71巻9号

2017年09月発行

今月の臨床 着床不全・流産をいかに防ぐか─PGS時代の不妊・不育症診療ストラテジー 母体・子宮側因子による流産・不育症

血液凝固異常症─第Ⅻ因子・プロテインS欠乏症を含めて

著者： 藤田太輔¹ 寺井義人¹ 大道正英¹

所属機関： ¹大阪医科大学産婦人科学教室

ページ範囲：P.836 - P.845

●第Ⅻ因子欠乏症は，出血性素因がなく，血栓性素因に関しても証明されていない．また不育症との関連性についても不明である．

●プロテインS欠乏症は本邦における先天性血栓性素因のなかで最も頻度が高い．静脈血栓塞栓症のリスク因子であり，不育症（特に妊娠中期・後期死産）との関連がある．

●第Ⅻ因子欠乏症合併妊娠とプロテインS欠乏症合併妊娠の問題点は，不育症の治療目的で抗血小板療法や抗凝固療法をすべきかどうかについて確固たるエビデンスがない点である．

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