臨床婦人科産科72巻1号

2018年01月発行

合併増大号　今月の臨床 産婦人科感染症の診断・管理─その秘訣とピットフォール HPV感染症

HPV検査の活用法

著者： 村上功¹ 岩田卓² 森定徹² 青木大輔²

所属機関： ¹国立病院機構東京医療センター産婦人科 ²慶應義塾大学医学部産婦人科学教室

ページ範囲：P.150 - P.157

●HPV検査は，ハイリスクHPV一括検査とHPVタイピング検査に大別される．おのおのの特性および適応についての理解が必要である．

●HPV検査を取り入れた検診のメリットは，病変の発見感度の向上と検診間隔を延長できる可能性である．ただし特異度の問題，検診のマネジメント面での問題など，解決すべき問題点が存在する．

●子宮頸がん検診は一般市民に対してより一層の啓発活動や受診推進が必要である．さらに，検診手法の合理化や検診間隔の適正化についての検討も急務である．

参考文献

1）Koss LG : The Papanicolaou test for cervical cancer detection. A triumph and tragedy. JAMA 261 : 737─743, 1989

2）Michalas SP : A screening test for the prevention of cancer of uterine cervix. Eur J Obstet Gynecol Reprod Biol 90 : 135─138, 2000

3）Zur Hauzen H : Papillomaviruses and cancer : from basic studies to clinical application. Nat Rev Cancer 2 : 342─350, 2002

4）Burd EM : Human papillomavirus and cervical cancer. Clin Microbiol Rev 16 : 1─17, 2003

5）Ozaki S, et al : Analytical performance of newly developed multiplex human papillomavirus genotyping assay using Luminex xMAPTM technology（MebgenTMHPV Kit）. J Virolog Meth 204 : 73─80, 2014

6）Morimura Y, et al : A twenty year period in mass screening for uterine cervical cancer in Fukushima Prefecture. Fukushima J Med Sci 44 : 59─67, 1998

7）Bosch FX, et al : The casual relation between human papillomavirus and cervical cancer. J Clin Pathol 55 : 244─265, 2002

8）HPV and cervical cancer in the world 2007 report. Vaccine 25 : S3, 2007

9）Cervical cancer screening : IARC handbooks of cancer prevention Vol.10. pp122─211, IARC Press

10）ACOG Practice Bulletin : clinical management guidelines for obstetrician-gynecologists. Number 45, 2003

11）Morisada T, et al : CITRUS, cervical cancer screening trial by randomization of HPV testing intervention for upcoming screening ; design, methods and baseline data of 18,471 women. Cancer Epidemiol 50 : 60─67, 2017

12）日本産科婦人科学会/日本産婦人科医会 : 産婦人科診療ガイドライン─婦人科外来編 2017, 2017

13）Moscicki AB : HPV infections in adolescents. Dis Markers 23 : 229─234, 2007

14）Matsumoto K, et al : IgG antibodies to human papillomavirus 16, 52, 58, and 6 L1 capsids ; case-control study of cervical intraepithelial neoplasia in Japan. J Med Virol 69 : 411─446, 2003

15）Munoz N, et al : Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348 : 518─527, 2003

16）Miura S, et al : Do we need difference strategy for HPV screening and vaccination in East Aisa? Int J Cancer 119 : 2713─2715, 2006

17）Onuki M, et al : Human papillomavirus infections among Japanese women : age-related prevalence and type-specific risk for cervical cancer. Cancer Sci 100 : 1312─1316, 2009

18）Sasagawa T, et al : Population-based study for human papillomavirus（HPV） infection in young women in Japan ; a multicenter study by the Japanese human papillomavirus disease education research survey group（J-HERS）. J Med Virol 88 : 324─335, 2016

19）de Sanjosé S, et al : Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology ; a meta-analysis. Lancet Infec Dis 7 : 453─459, 2007

20）Nishiwaki M, et al : Genotyping of human papillomaviruses by a novel one-step typing method with multiplex PCR and clinical applications. J Clin Microbiol 46 : 1161─1168, 2008

21）Kondo K, et al : Genotype distribution of human papillomaviruses in Japanese women with abnormal cytrology. Open Virol J 6 : 277─283, 2012

22）Matsumoto K, et al : Predicting the progression of cervical precursor lesions by human papillomavirus genotyping ; a prospective cohort study. Int J Cancer 128 : 2898─2910, 2011

23）ASCUS-LSIL traige study（ALTS） group : Results of a randomized trial on the management of cytology interpretations of atypical squamous cells of undetermined significance. Am J Obstet Gynecol 188 : 1383─1392, 2003

24）Rijkaart DC, et al : Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer ; final results of the POBASCAM randomised controlled trial. Lancet Oncol 13 : 78─88, 2012

25）Eklund C, et al : Global improvement in genotyping of human papillomavirus DNA ; the 2011 HPV LabNet international proficiency study. J Clin Microbiol 52 : 449─459, 2014