臨床婦人科産科72巻2号

2018年03月発行

今月の臨床 ホルモン補充療法ベストプラクティス─いつから始める？　いつまで続ける？　何に注意する？ 効果と注意点（発がんリスクを除いて）

HRT開始時期─タイミング仮説

著者： 篠原康一¹

所属機関： ¹愛知医科大学産婦人科

ページ範囲：P.238 - P.243

●心血管系の有害事象を減らすためにHRTの開始時期・開始年齢を考慮すべきである．

参考文献

1）Rossouw JE, et al : Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA 297 : 1465─1477, 2007

2）Manson JE, et al : Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials. JAMA 310 : 1353─1368, 2013

3）Schierbeck LL, et al : Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women : randomised trial. BMJ 345 : e6409, 2012

4）Salpeter SR, et al : Coronary heart disease events associated with hormone therapy in younger and older women. A meta-analysis. J Gen Intern Med 21 : 363─366, 2006

5）de Villiers TJ, et al : Revised global consensus statement on menopausal hormone therapy. Climacteric 19 : 313─315, 2016

6）Boardman HM, et al : Hormone therapy for preventing cardiovascular disease in post-menopausal women. Cochrane Database Syst Rev 3 : CD002229, 2015

7）Harman SM, et al : Arterial imaging outcomes and cardiovascular risk factors in recently menopausal women : a randomized trial. Ann Intern Med 161 : 249─260, 2014

8）Hodis HN, et al : Methods and baseline cardiovascular data from the Early versus Late Intervention Trial with Estradiol testing the menopausal hormone timing hypothesis. Menopause 22 : 391─401, 2015

9）Hodis HN, et al : Estrogen in the prevention of atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 135 : 939─953, 2001

10）Hodis HN, et al : Vascular effects of early versus late postmenopausal treatment with estradiol. N Engl J Med 374 : 1221─1231, 2016

11）Grodstein F, et al : The epidemiology of coronary heart disease and estrogen replacement in postmenopausal women. Prog Cardiol Dis 38 : 199─210, 1995

12）Grodstein F, et al : Estrogen for women at varying risk of coronary disease. Maturitas 30 : 19─26, 1998

13）LaCroix AZ, et al : Health outcomes after stopping conjugated equine estrogens among postmenopausal women with hysterectomy : a randomized controlled trial. JAMA 305 : 1305─1314, 2011

14）Rossouw JE, et al : Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA 297 : 1465─1477, 2007

15）Salpeter SR, et al : Mortality associated with hormone replacement therapy in younger and older women : a meta-analysis. J Gen Intern Med 19 : 791─804, 2004