臨床婦人科産科73巻10号

2019年10月発行

今月の臨床 進化する子宮筋腫診療―診断から最新治療・合併症まで

病因論

子宮筋腫の進展因子

著者： 杉野法広¹ 佐藤俊¹ 前川亮¹

所属機関： ¹山口大学大学院医学系研究科産科婦人科学講座

ページ範囲：P.941 - P.950

文献概要

●子宮筋腫の病態は，子宮平滑筋細胞の細胞増殖能の亢進と細胞外基質の増加である．

●子宮筋腫では，ゲノムワイドに多くの遺伝子のDNAメチル化異常と発現異常が起こっている．

●DNAメチル化異常による少数の上流遺伝子の発現異常によって，その下流の多くの遺伝子の発現異常が引き起こされ，細胞増殖と細胞外基質産生が亢進し，子宮筋腫が発生・発育する．

●性ホルモンの直接的な制御下にある遺伝子のうち，プロモーターにDNAメチル化異常を受けた遺伝子群が，初経後の性ホルモンの曝露により発現異常を起こし，細胞増殖と細胞外基質産生が亢進する．

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