臨床婦人科産科73巻10号

2019年10月発行

今月の臨床 進化する子宮筋腫診療―診断から最新治療・合併症まで

薬物療法

ウリプリスタールの作用機序と使い方

著者： 伊藤文武¹ 北脇城¹

所属機関： ¹京都府立医科大学大学院医学研究科女性生涯医科学

ページ範囲：P.966 - P.971

文献概要

●子宮筋腫の増大にはプロゲステロンが重要である．

●ウリプリスタールはプロゲステロン受容体に結合し，コアクチベーターとコリプレッサーの両者と結合し転写の活性と抑制を制御する．

●ウリプリスタールの筋腫に対する効果はリュープロレリンに対し非劣性であり，エストロゲン分泌が保たれるためエストロゲン欠落症状の出現頻度が少ない．

参考文献

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