臨床婦人科産科73巻2号

2019年03月発行

今月の臨床 NIPT新時代の幕開け―検査の実際と将来展望 NIPTの基礎

欧米ではNIPTはどの程度普及しているか？

著者： 和泉美希子¹² 関沢明彦³

所属機関： ¹昭和大学病院臨床遺伝医療センター ²昭和大学病院産婦人科 ³昭和大学医学部産婦人科学講座

ページ範囲：P.194 - P.198

●NIPT受託サービスは欧米のみならず世界の多くの国々で展開されているが，各国の導入の状況はさまざまである．

●NIPTの普及によって，欧米では従来の侵襲的な出生前検査の実施数は減少している．

参考文献

1）Allyse M, et al : Non-invasive prenatal testing : a review of international implementation and challenges. Int J Womens Health 7 : 113-126, 2015

2）Minear MA, et al : Global perspectives on clinical adoption of NIPT. Prenat Diagn 35 : 959-967, 2015

3）Chitty LS, et al : Uptake, outcomes, and costs of implementing non-invasive prenatal testing for Down's syndrome into NHS maternity care : prospective cohort study in eight diverse maternity units. Bmj-Brit Med J 354 : i3426, 2016

4）van Schendel RV, et al : Implementing non-invasive prenatal testing for aneuploidy in a national healthcare system : global challenges and national solutions. BMC Health Serv Res 17 : 670, 2017

5）Larion S, et al : Association of combined first-trimester screen and noninvasive prenatal testing on diagnostic procedures. Obstet Gynecol 123 : 1303-1310, 2014

6）Bjerregaard L, et al : The rate of invasive testing for trisomy 21 is reduced after implementation of NIPT. Dan Med J 64 : A5359, 2017

7）Martínez-Payo C, et al : Clinical results after the implementation of cell-free fetal DNA detection in maternal plasma. J Obstet Gynaecol Res 44 : 1369-1376, 2018

8）Hill M, et al : Has noninvasive prenatal testing impacted termination of pregnancy and live birth rates of infants with Down syndrome? Prenat Diagn 37 : 1281-1290

9）Morris JK, et al : Trends in Down's syndrome live births and antenatal diagnoses in England and Wales from 1989 to 2008 : analysis of data from the National Down Syndrome Cytogenetic Register. BMJ 339 : b3794, 2009

10）de Graaf G, et al : Estimates of the live births, natural losses, and elective terminations with Down syndrome in the United States. Am J Med Genet A 167A : 756-767, 2015