臨床婦人科産科73巻3号

2019年04月発行

今月の臨床 いまさら聞けない　体外受精法と胚培養の基礎知識

胚培養の実際

未熟卵が採卵された場合にどうするか？

著者： 河村寿宏¹ 竹村由里¹² 片瀬世莉那¹

所属機関： ¹田園都市レディースクリニック ²帝京大学医学部附属溝口病院

ページ範囲：P.365 - P.371

文献概要

●未熟卵の採卵を避けるためには，適切な刺激法と卵胞径やE₂値などから判断される採卵決定のタイミング，トリガーの方法が重要である．

●採卵時未熟卵だった場合の培養として，IVM mediumやblastocyst mediumを使用する方法，卵胞液，卵丘細胞を使用する方法，成長因子を添加する方法，などが試みられているが，いずれもまだ確立された方法ではない．

●未熟卵で採取されても，採卵当日のうちにMⅡ卵に成熟した卵子にICSIを実施した場合，採卵時MⅡ卵に比し，受精率・良好胚率は低下するが，胚盤胞に到達した胚の妊娠率は良好である．

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