臨床婦人科産科74巻12号

2020年12月発行

今月の臨床 着床環境の改善はどこまで可能か？―エキスパートに聞く最新研究と具体的対処法 子宮内感染

子宮内細菌叢と生殖補助医療との関係

著者： 齋藤早貴¹ 山田満稔¹

所属機関： ¹慶應義塾大学医学部産婦人科学教室

ページ範囲：P.1236 - P.1240

●分子生物学の進歩により，腟・子宮腔・卵管・腹腔内で構成の異なる常在細菌叢の存在が明らかとなってきた．

●子宮内細菌叢に占めるLactobacillus属の割合と体外受精成績の相関が報告されている．

●妊娠成立における子宮内細菌叢の生物学的な意義は明らかとなっていない．

参考文献

1）Bobitt JR, et al : Unrecognized amnionitis and prematurity : a preliminary report. Reprod Med 19 : 8-12, 1977

2）Haahr T, et al : Abnormal vaginal microbiota may be associated with poor reproductive outcomes : a prospective study in IVF patients. Hum Reprod 31 : 795-803, 2016

3）Moreno I, et al : Evidence that the endometrial microbiota has an effect on implantation success or failure. Am J Obstet Gynecol 215 : 684-703, 2016

4）Fettweis JM, et al : The vaginal microbiome and preterm birth. Nat Med 25 : 1012-1021, 2019

5）Walther-António MRS, et al : Potential contribution of the uterine microbiome in the development of endometrial cancer. Genome Med 8 : 1-15, 2016

6）Ansbacher R, et al : Sterility of the uterine cavity. Am J Obstet Gynecol 99 : 394-396, 1967

7）Hemsell DL, et al : Endometrial bacteria in asymptomatic, nonpregnant women. J Reprod Med 34 : 872-874, 1989

8）Duff P, et al : Endometrial culture techniques in puerperal patients. Obstet Gynecol 61 : 217-222, 1983

9）Pelzer ES, et al : Microorganisms within human follicular fluid : effects on IVF. PLoS One 8 : e59062, 2013

10）Mitchell CM, et al : Colonization of the upper genital tract by vaginal bacterial species in nonpregnant women. Am J Obstet Gynecol 212 : 611.e1-611.e9, 2015

11）Peterson J, et al : The NIH human microbiome project. Genome Res 19 : 2317-23, 2009

12）Chen C, et al : The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases. Nat Commun 8 : 875, 2017

13）Ono C, et al : Staphylococcus epidermidis is involved in a mechanism for female reproduction in mice. Regen Ther 1 : 11-17, 2015

14）Selman H, et al : Examination of bacterial contamination at the time of embryo transfer, and its impact on the IVF/pregnancy outcome. J Assist Reprod Genet 24 : 395-399, 2007

15）Salim R, et al : Bacterial colonization of the uterine cervix and success rate in assisted reproduction : Results of a prospective survey. Hum Reprod 17 : 337-340, 2002

16）Moore DE, et al : Bacteria in the transfer catheter tip influence the live-birth rate after in vitro fertilization. Fertil Steril 74 : 1118-1124, 2000

17）Fanchin R, et al : Microbial flora of the cervix assessed at the time of embryo transfer adversely affects in vitro fertilization outcome. Fertil Steril 70 : 866-870, 1998

18）Egbase PE, et al : Incidence of microbial growth from the tip of the embryo transfer catheter after embryo transfer in relation to clinical pregnancy rate following in-vitro fertilization and embryo transfer. Hum Reprod 11 : 1687-1689, 1996

19）Franasiak JM, et al : Endometrial microbiome at the time of embryo transfer : next-generation sequencing of the 16S ribosomal subunit. J Assist Reprod Genet 33 : 129-136, 2016