1)Ehrmann DA : Polycystic ovary syndrome. N Engl J Med 352 : 1223-1236, 2005
2)De Leo V, et al : Insulin-lowering agents in the management of polycystic ovary syndrome. Endocr Rev 24 : 633-667, 2003
3)Rosenfield RL, et al : The pathogenesis of polycystic ovary syndrome(PCOS) : the hypothesis of PCOS as functional ovarian hyperandrogenism revisited. Endocr Rev 37 : 467-520, 2016
4)Jayasena CN, et al : The management of patients with polycystic ovary syndrome. Nat Rev Endocrinol 10 : 624-636, 2014
5)苛原 稔,他 : 生殖・内分泌委員会報告「本邦における多嚢胞卵巣症候群の新しい診断基準の設定に関する小委員会」報告.日産婦会誌59 : 868-886,2007
6)久保田俊郎,他 : 生殖・内分泌委員会報告「本邦における多嚢胞性卵巣症候群の治療法に関する治療方針作成のための小委員会」報告.日産婦会誌61 : 902-912,2009
7)Ferrannini E, et al : The target of metformin in type 2 diabetes. N Engl J Med 371 : 1547-1548, 2014
8)Madiraju AK, et al : Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature 510 : 542-546, 2014
9)高橋俊文 : 無排卵・機能性不妊に対する卵巣刺激 クロミフェン・メトホルミン.臨婦産73 : 637-642, 2019
10)Moghetti P, et al : Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome : a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation. J Clin Endocrinol Metab 85 : 139-146, 2000
11)Tang T, et al : Insulin-sensitising drugs(metformin, rosiglitazone, pioglitazone, D-chiro-inositol)for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database Syst Rev (5) : CD003053, 2012
12)Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group : Consensus on infertility treatment related to polycystic ovary syndrome. Fertil Steril 89 : 505-522, 2008
13)Nestler JE, et al : Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. N Engl J Med 338 : 1876-1880, 1998
14)Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group : Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome(PCOS). Hum Reprod 19 : 41-47, 2004
15)Tso LO, et al : Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome. Cochrane Database Syst Rev (11) : CD006105, 2014
16)Al-Inany HG, et al : Gonadotrophin-releasing hormone antagonists for assisted reproductive technology. Cochrane Database Syst Rev(4) : CD001750, 2016
17)Practice Committee of the American Society for Reproductive Medicine : Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome(PCOS) : a guideline. Fertil Steril 108 : 426-441, 2017
18)Glueck CJ, et al : Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin. Hum Reprod 17 : 2858-2864, 2002
19)Mikola M, et al : Obstetric outcome in women with polycystic ovarian syndrome. Hum Reprod 16 : 226-229, 2001
20)Palomba S, et al : Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome : a systematic review and meta-analysis of randomized controlled trials. Fertil Steril 92 : 1646-1658, 2009
21)Vanky E, et al : Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome : a randomized, controlled multicenter study. J Clin Endocrinol Metab 95 : E448-455, 2010