臨床婦人科産科75巻1号

2021年01月発行

合併増大号　今月の臨床 生殖医療の基礎知識アップデート―患者説明に役立つ最新エビデンス・最新データ

生殖補助医療

PGT-Aの現状

著者： 佐藤剛¹

所属機関： ¹名古屋市立大学大学院医学研究科産科婦人科学

ページ範囲：P.134 - P.143

文献概要

●PGT-Aにより胚移植あたりの妊娠率，生児獲得率に改善がみられることが報告されているが，症例あたりの有用性は示されていない．

●モザイク胚の存在はPGT-Aの解析精度に影響を与え，その取り扱いについては議論が続いている．

●近年，niPGT-Aに関する研究が盛んに行われ，その精度の向上や効果が報告されており，今後の普及と臨床への早期の導入が期待される．

●日本でのPGT-Aの多施設共同研究が現在進行中である．そのパイロット試験では，胚移植あたりの臨床妊娠率，生産率は，PGT-A群で改善がみられたが，症例あたりでは対照群と差がなかった．

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