臨床婦人科産科75巻3号

2021年04月発行

今月の臨床 女性のライフステージごとのホルモン療法―この1冊ですべてを網羅する 月経異常・不妊

不妊治療での内膜の調整周期

著者： 山下能毅¹² 大道正英²

所属機関： ¹うめだファティリティークリニック ²大阪医科大学産婦人科

ページ範囲：P.320 - P.325

●凍結融解胚移植を行う場合は，ホルモン補充周期で行われることが多い．

●自然周期移植とホルモン補充周期の臨床成績はほぼ同等である．

●反復不成功症例には，内膜スクラッチや子宮内膜受容能検査（ERA）も考慮する．

参考文献

1）Roque M, et al : Fresh embryo transfer versus frozen embryo transfer in in vitro fertilization cycles : a systemic review and meta-analysis. Fertil Steril 99 : 156-162, 2013

2）Rinaldi L, et al : Endometrial thickness as a predictorof pregnancy after in-vitro fertilization but not after intracytoplasmic sperm injection. Hum Reprod 11 : 1538-1541, 1996

3）Geyter CD, et al : Prospective evaluation of the ultrasound appearance of the endometrium in a cohort of 1,186 infertile women. Fertil Steril 73 : 106-113, 2000

4）Diaz-Gimeno, et al : A genomic diagnosis tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril 95 : 50-60, 2011

5）Shapiro BS, et al : Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization : a prospective randomized trial comparing fresh and frozen-thawed embryo transfers. Fertil Steril 96 : 344-348, 2011

6）Givens CR, et al : Outcomes of natural cycles versus programmed cycles for 1677 frozen thawed embryo transfers. Reprod Biomed Online 19 : 380-384, 2009

7）Ruiz Alonso M, et al : The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure. Fertil Steril 100 : 818-824, 2013

8）Simon C, et al : Prize PaperASRM Annual Meeting 2016

9）Olesen MS, et al : Therapeutic endometrial scratching and implantation after in vitro fertilization : a multicenter randomized controlled trial. Fertil Steril 112 : 1015-1021, 2019

10）Saito K, et al : Endometrial preparation methods for frozen-thawed embryo transfer are associated with altered risks of hypertensive disorders of pregnancy, placenta accreta, and gestational diabetes mellitus. Hum Reprod 34 : 1567-1575, 2019