臨床婦人科産科76巻10号

2022年10月発行

今月の臨床 女性医学から読み解くメタボリック症候群―専門医のための必須知識

女性ホルモンとの関係

内臓脂肪型肥満に対する女性ホルモンの影響

著者： 小林範子¹

所属機関： ¹北海道大学病院婦人科

ページ範囲：P.950 - P.957

文献概要

●閉経後は，エストロゲンの減少によりSHBG産生が低下してテストステロン優勢となり，内臓脂肪が増加する．

●エストロゲンは脂肪分解を促進し，脂肪蓄積を抑制する作用がある．

●エストロゲンの脂肪分解，合成の機序にはLPL，PPARγなど，さまざまな因子の関連がみられる．

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