臨床婦人科産科76巻10号

2022年10月発行

今月の臨床 女性医学から読み解くメタボリック症候群―専門医のための必須知識 疾患・分野別編

妊娠高血圧症候群とメタボリック症候群

著者： 増山寿¹

所属機関： ¹岡山大学学術研究院医歯薬域産科・婦人科学

ページ範囲：P.1000 - P.1005

●妊娠高血圧症候群（HDP）は，母体は早産，子癇，常位胎盤早期剝離など，児は胎児発育不全（FGR）を合併しやすい重要な周産期疾患である．

●HDP罹患女性は将来メタボリック症候群や心血管疾患の発症リスクが上昇することが知られている．

●HDP罹患母体から出生した児も，将来メタボリック症候群や心血管疾患発症リスクが高いと報告されており，継続的なフォローアップ体制の構築が必要である．

参考文献

1）増山　寿 : 妊娠高血圧症候群up to date．日本周産期・新生児会誌56 : 642-644, 2021

2）World Health Organization : Definition, diagnosis and classification of diabetes mellitus and its complications : report of a WHO consultation. Part 1, Diagnosis and classification of diabetes mellitus. World Health Organization, Geneva, 1999．http://www.who.int/iris/handle/10665/66040

3）Roberts JM : Preeclampsia : What we know and what we do not know. Semin Perinatol 24 : 24-28, 2000

4）Masuyama H, et al : Different profiles of circulating angiogenic factors and adipocytokines between early- and late-onset preeclampsia. BJOG 117 : 314-320, 2010

5）Carty DM, et al : Preeclampsia and future maternal health. J Hypertens 28 : 1349-1355, 2010

6）Garovic VD, et al : Incidence and Long-Term Outcomes of Hypertensive Disorders of Pregnancy. J Am Coll Cardiol 75 : 2323-2334, 2020

7）Jenabi E, et al : The association between preeclampsia and the risk of metabolic syndrome after delivery : a meta-analysis. J Matern Fetal Neonatal Med 34 : 3253-3258, 2021

8）Kurabayashi T, et al : Pregnancy-induced hypertension is associated with maternal history and a risk of cardiovascular disease in later life : Japanese cross-sectional study. Maturitas 75 : 227-231, 2013

9）Turbeville HR, et al : Preeclampsia beyond pregnancy : long-term consequences for mother and child. Am J Physiol Renal Physiol 318 : F1315-F1326, 2020

10）Barker DJP : The fetal and infant origins of adult disease. BMJ 301 : 1111, 1990

11）Gluckman PD, et al : Living with the past : evolution, development and patterns of disease. Science 305 : 1733-1736, 2004

12）Masuyama H, et al : Effects of a high-fat diet exposure in utero on the metabolic syndrome-like phenomenon in mouse offspring through epigenetic changes in adipocytokine gene expression. Endocrinology 153 : 2823-2830, 2012

13）Behrman JR, et al : Nutritional supplementation in girls influences the growth of their children : prospective study in Guatemala. Am J Clin Nutr 90 : 1372-1379, 2009

14）塩崎有宏，他 : SGA児の発症原因，次世代への予防医療　DOHaDを活かす．産と婦10 : 1209-1214, 2017

15）Silveira VM, et al : Birth weight and metabolic syndrome in adults : meta-analysis. Rev Saude Publica 42 : 10-18, 2008

16）Harder T, et al : Birth weight and subsequent risk of type 2 diabetes : a meta-analysis. Am J Epidemiol 165 : 849-857, 2007

17）Mu M, et al : Birth weight and subsequent blood pressure : a meta-analysis. Arch Cardiovasc Dis 105 : 99-113, 2012

18）Zhao Y, et al : Birth weight and overweight/obesity in adults : a meta-analysis. Eur J Pediatr 171 : 1737-1746, 2012

19）Bi S, et al : Long-term effects of preeclampsia on metabolic and biochemical outcomes in offspring : what can be expected from a meta-analysis? Obes Rev 23 : e13411, 2022

20）Vatten LJ, et al : Intrauterine exposure to preeclampsia and adolescent blood pressure, body size and age at menarche in female offspring. Obstet Gynecol 101 : 529-533, 2003

21）Karatza AA, et al : Preeclampsia emerging as a novel risk factor for cardiovascular disease in the offspring. Curr Pediatr Rev 16 : 194-199, 2020

22）Mitsui T, et al : Sex differences in early growth during the first three years of life in offspring from mothers with pregnancy-induced hypertension. Pregnancy Hypertens 6 : 361-366, 2016

23）Stettler N, et al : Infant weight gain and childhood overweight status in a multicenter, cohort study. Pediatrics 109 : 194-199, 2002

24）Ogland B, et al : Pubertal anthropometry in sons and daughters of women with preeclamptic or normotensive pregnancies, Arch Dis Childhood 94 : 855-859, 2009