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雑誌文献

臨床婦人科産科76巻10号

2022年10月発行

文献概要

今月の臨床 女性医学から読み解くメタボリック症候群―専門医のための必須知識 最新治療編

肥満に対する最新治療―抗肥満薬の現状と未来

著者: 上野浩晶1

所属機関: 1宮崎大学医学部内科学講座血液・糖尿病・内分泌内科学分野

ページ範囲:P.1028 - P.1034

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●内因性の摂食調節ペプチドを応用した抗肥満薬が多数開発中である.

●半減期を長くした週1回投与製剤や,皮下注射ではなく経口投与が可能な製剤も開発されている.

●複数の摂食調節ペプチドの構造を併せ持ち,より強力な摂食抑制作用を示す薬剤も臨床応用されつつある.

参考文献

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12)Killion EA, et al : Chronic glucose-dependent insulinotropic polypeptide receptor(GIPR)agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism. Nat Commun 11 : 4981, 2020
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14)Frias JP, et al : The sustained effects of a dual GIP/GLP-1 receptor agonist, NNC0090-2746, in patients with type 2 diabetes. Cell Metab 26 : 343-352. e2, 2017
15)Del Prato S, et al : Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk(SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial. Lancet 398 : 1811-1824, 2021
16)Schiavon M, et al : Improved postprandial glucose metabolism in type 2 diabetes by the dual glucagon-like peptide-1/glucagon receptor agonist SAR425899 in comparison with liraglutide. Diabetes Obes Metab 23 : 1795-1805, 2021
17)Asano M, et al : Pharmacokinetics, safety, tolerability and efficacy of cotadutide, a glucagon-like peptide-1 and glucagon receptor dual agonist, in phase 1 and 2 trials in overweight or obese participants of Asian descent with or without type 2 diabetes. Diabetes Obes Metab 23 : 1859-1867, 2021
18)Nahra R, et al : Effects of cotadutide on metabolic and hepatic parameters in adults with overweight or obesity and type 2 diabetes : a 54-week randomized hase 2b study. Diabetes Care 44 : 1433-1442, 2021
19)Ji L, et al : IBI362(LY3305677), a weekly-dose GLP-1 and glucagon receptor dual agonist, in Chinese adults with overweight or obesity : a randomised, placebo-controlled, multiple ascending dose phase 1b study. EClinicalMedicine 39 : 101088, 2021
20)Finan B, et al : A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Nat Med 21 : 27-36, 2015

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1294

印刷版ISSN:0386-9865

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