臨床婦人科産科76巻11号

2022年11月発行

今月の臨床 生殖医療の安全性―どんなリスクと留意点があるのか？ 受精卵，児・家族への影響

受精卵・出生児・胎盤の遺伝子変異

著者： 濱田裕貴¹² 宮内尚子¹ 有馬隆博¹

所属機関： ¹東北大学大学院医学系研究科情報遺伝学分野 ²東北大学病院産婦人科

ページ範囲：P.1134 - P.1139

●受精卵から初期胚へ細胞分裂が起こる際，エピジェネティクス（遺伝子発現を制御する修飾分子）の変化が生じる．

●生殖補助医療（ART）由来出生児では，インプリンティング異常症などの先天性疾患，周産期合併症に加え，自閉症・発達障害や成人期の生活習慣病（肥満，高血圧など）との関連性が注目されている．

●今後，安全なART治療を実施するうえで，遺伝子およびエピゲノムによる評価と管理が重要となる．

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