臨床婦人科産科76巻4号

2022年04月発行

増刊号 最新の不妊診療がわかる！―生殖補助医療を中心とした新たな治療体系

第2章　生殖補助医療とその手技 胚移植と子宮内環境―良好な子宮内環境に受精卵を確実に移植する

免疫操作法（2）―アスピリン・ヘパリン・免疫グロブリン・脂肪乳剤・プレドニゾロン・ヒドロキシクロロキン

著者： 福井淳史¹ 山谷文乃¹ 柴原浩章¹

所属機関： ¹兵庫医科大学産科婦人科

ページ範囲：P.111 - P.116

文献概要

▶着床期の子宮内膜にはT細胞，NK細胞などの免疫担当細胞が存在し，妊娠の成立・維持に重要な役割を果たしている．
▶T細胞，NK細胞などの免疫担当細胞の異常を有する反復着床不全症例に対して免疫調整療法が有効である可能性がある．
▶反復着床不全症例に対する免疫調整薬として，アスピリン，ヘパリン，免疫グロブリン，脂肪乳剤，プレドニゾロン，ヒドロキシクロロキンなどが試みられている．

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