臨床婦人科産科76巻7号

2022年07月発行

今月の臨床 子宮内膜症の最新知識―この1冊で重要ポイントを網羅する

がん化

がん化のメカニズム

著者： 山口建¹

所属機関： ¹京都大学大学院医学研究科婦人科学産科学教室

ページ範囲：P.682 - P.689

文献概要

●卵巣明細胞癌の発生にはARID1A遺伝子変異，PIK3CA遺伝子変異，TP53の機能抑制がかかわり，SWI/SNF複合体，PI3K-mTOR経路が重要である．

●卵巣類内膜癌の発生にはCTNNB1遺伝子変異，PTEN遺伝子変異がかかわり，βカテニン経路にかかわるAPCやPTENが重要である．またERが高発現しており，女性ホルモン依存性がある．

●子宮内膜症性囊胞というストレス環境のなかで発生する卵巣明細胞癌は，HNF1Bによってミトコンドリアの機能を抑え，エネルギー代謝異常を起こすことでストレスに耐性の性格をもつ．

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