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臨床婦人科産科77巻1号

2023年01月発行

文献概要

合併増大号 今月の臨床 最善で最新の産科麻酔診療をめざして 分娩時の麻酔―硬膜外無痛分娩

硬膜外鎮痛による児の長期的影響

著者: 中畑克俊1

所属機関: 1関西医科大学附属病院麻酔科・総合周産期母子医療センター

ページ範囲:P.138 - P.144

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●脊髄幹麻酔は,児の学習障害のリスクを増加させない.

●分娩時の硬膜外鎮痛は,出生後の児の発達に悪影響を及ぼさない.

●硬膜外無痛分娩と自閉スペクトラム症との関係を示唆する報告が話題となっているが,これを支持する強いエビデンスはない.

参考文献

1)Loftus JR, et al : Fetal heart rate after epidural lidocaine and bupivacaine for elective cesarean section. Anesthesiology 75 : 406-412, 1991
2)Bader AM, et al : Maternal and neonatal fentanyl and bupivacaine concentrations after epidural infusion during labor. Anesth Analg 81 : 829-832, 1995
3)Vertommen JD, et al : The effects of the addition of sufentanil to 0.125%bupivacaine on the quality of analgesia during labor and on the incidence of instrumental deliveries. Anesthesiology 74 : 809-814, 1991
4)Abrão KC, et al : Elevation of uterine basal tone and fetal heart rate abnormalities after labor analgesia : a randomized controlled trial. Obstet Gynecol 113 : 41-47, 2009
5)Anim-Somuah M, et al : Epidural versus non-epidural or no analgesia for pain management in labour. Cochrane Database Syst Rev 5 : CD000331, 2018
6)Sprung J, et al : Anesthesia for cesarean delivery and learning disabilities in a population-based birth cohort. Anesthesiology 111 : 302-310, 2009
7)Flick RP, et al : Neuraxial labor analgesia for vaginal delivery and its effects on childhood learning disabilities. Anesth Analg 112 : 1424-1431, 2011
8)Kearns RJ, et al : Association of epidural analgesia in women in labor with neonatal and childhood outcomes in a population cohort. JAMA Netw Open 4 : e2131683, 2021
9)Rosen MA : Nitrous oxide for relief of labor pain : a systematic review. Am J Obstet Gynecol 186(Suppl) : S110-S126, 2002
10)Saito M, et al : Prevalence and cumulative incidence of autism spectrum disorders and the patterns of co-occurring neurodevelopmental disorders in a total population sample of 5-year-old children. Mol Autism 11 : 35, 2020
11)Qiu C, et al : Association between epidural analgesia during labor and risk of autism spectrum disorders in offspring. JAMA Pediatr 174 : 1168-1175, 2020
12)The Society for Obstetric Anesthesia and Perinatology(SOAP). Labor epidurals do not cause autism : safe for mothers and infants, say anesthesiology, obstetrics, and pediatric medical societies. Joint Statement of the Society for Obstetric Anesthesia and Perinatology, American Society of Anesthesiologists, Society for Pediatric Anesthesia, American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine. October 12, 2020 https://soap.memberclicks.net/assets/docs/JAMAPeds_Epidurals_SOAP_ASA_SPA_ACOG_SMFM_Media_Response_101220%20%281%29.pdf
13)Saito M, et al : Concerns for labor analgesia and autism spectrum disorders. J Anesth 35 : 319-320, 2021
14)Carrier FM, et al : Epidural analgesia during labour and autism risk : getting lost on the causal path. Can J Anaesth 68 : 277-284, 2021
15)Lord C, et al : Autism spectrum disorder. Nat Rev Dis Primers 6 : 5, 2020
16)Wall-Wieler E, et al : Association of epidural labor analgesia with offspring risk of autism spectrum disorders. JAMA Pediatr 175 : 698-705, 2021
17)Mikkelsen AP, et al : Association of labor epidural analgesia with autism spectrum disorder in children. JAMA 326 : 1170-1177, 2021
18)Hanley GE, et al : Association of epidural analgesia during labor and delivery with autism spectrum disorder in offspring. JAMA 326 : 1178-1185, 2021
19)Murphy MSQ, et al : Exposure to intrapartum epidural analgesia and risk of autism spectrum disorder in offspring. JAMA Netw Open 5 : e2214273, 2022

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1294

印刷版ISSN:0386-9865

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