臨床婦人科産科77巻12号

2023年12月発行

今月の臨床 AIがもたらす産婦人科医療の変革

生殖医療

AIを用いた胚画像認識と臨床データ解析の融合による妊娠予測

著者： 江夏徳寿¹

所属機関： ¹英ウィメンズクリニック

ページ範囲：P.1216 - P.1221

文献概要

●タイムラプス動画を解析したAIシステムによる出産・非出産の予測は現時点でともに的中率50％を超えており，移植胚を選別する補助ツールになりうると考えられる．

●画像だけでなく，さまざまな臨床データを加えることによって精度が向上することが報告されており，今後の臨床応用が期待される．

参考文献

1）Gardner DK, et al : Culture and selection of viable blastocysts : a feasible proposition for human IVF? Hum Reprod Update 3 : 367-382, 1997

2）Gardner DK, et al : Assessment of human embryo development using morphological criteria in an era of time-lapse, algorithms and ‘OMICS’ : is looking good still important? Mol Hum Reprod 22 : 704-718, 2016

3）Haviland MJ, et al : Comparison of pregnancy outcomes following preimplantation genetic testing for aneuploidy using a matched propensity score design. Hum Reprod 35 : 2356-2364, 2020

4）Bhatt SJ, et al : Pregnancy outcomes following in vitro fertilization frozen embryo transfer（IVF-FET） with or without preimplantation genetic testing for aneuploidy（PGT-A） in women with recurrent pregnancy loss（RPL） : a SART-CORS study. Hum Reprod 36 : 2339-2344, 2021

5）Cornelisse S, et al : Preimplantation genetic testing for aneuploidies（abnormal number of chromosomes） in in vitro fertilisation. Cochrane Database Syst Rev 9 : CD005291, 2020

6）Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology ; Penzias A, et al : The use of preimplantation genetic testing for aneuploidy（PGT-A） : a committee opinion. Fertil Steril 109 : 429-436, 2018

7）Leaver M, et al : Non-invasive preimplantation genetic testing（niPGT）: the next revolution in reproductive genetics? Hum Reprod Update 26 : 16-42, 2019

8）VerMilyea M, et al : Development of an artificial intelligence-based assessment model for prediction of embryo viability using static images captured by optical light microscopy during IVF. Hum Reprod 35 : 770-784, 2020

9）Hill MJ, et al : Trophectoderm grade predicts outcomes of single-blastocyst transfers. Fertil Steril 99 : 1283-1289.e1, 2013

10）Annan JJK, et al : Biochemical pregnancy during assisted conception : a little bit pregnant. J Clin Med Res 5 : 269-274, 2013

11）Simon AL, et al : Pregnancy outcomes from more than 1,800 in vitro fertilization cycles with the use of 24-chromosome single-nucleotide polymorphism-based preimplantation genetic testing for aneuploidy. Fertil Steril 110 : 113-121, 2018

12）Enatsu N, et al : A novel system based on artificial intelligence for predicting blastocyst viability and visualizing the explanation. Reprod Med Biol 21 : e12443, 2022

13）Otsuki J, et al : Noninvasive embryo selection : kinetic analysis of female and male pronuclear development to predict embryo quality and potential to produce live birth. Fertil Steril 112 : 874-881, 2019

14）Hardarson T, et al : Human embryos with unevenly sized blastomeres have lower pregnancy and implantation rates : indications for aneuploidy and multinucleation. Hum Reprod 16 : 313-318, 2001

15）Yilmaz A, et al : Chromosomal complement and clinical relevance of multinucleated embryos in PGD and PGS cycles. Reprod Biomed Online 28 : 380-387, 2014

16）Magli MC, et al : Embryo morphology and development are dependent on the chromosomal complement. Fertil Steril 87 : 534-541, 2007

17）Minasi MG, et al : Correlation between aneuploidy, standard morphology evaluation and morphokinetic development in 1730 biopsied blastocysts : a consecutive case series study. Hum Reprod 31 : 2245-2254, 2016

18）Bamford T, et al : A comparison of 12 machine learning models developed to predict ploidy, using a morphokinetic meta-dataset of 8147 embryos. Hum reprod 38 : 569-581, 2023