臨床婦人科産科77巻2号

2023年03月発行

今月の臨床 子宮体がん診療の最前線―最新分類から治療法まで

薬物療法

―【がん免疫療法】―ミスマッチ修復（MMR）遺伝子機能欠損の評価法

著者： 百村麻衣¹ 小林陽一¹

所属機関： ¹杏林大学医学部産科婦人科学教室

ページ範囲：P.284 - P.291

文献概要

●ミスマッチ修復（MMR）遺伝子機能欠損を評価するスクリーニング検査にはマイクロサテライト不安定性（MSI）検査と免疫染色（IHC）がある．

●Lynch症候群は大腸がん，子宮体がん，卵巣がん，尿路がん，胃がんなどの関連腫瘍を好発する．

●MMR遺伝子別に関連腫瘍の発生頻度，発生時期が異なるため，カウンセリングやサーベイランスを行ううえで留意が必要である．

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