臨床婦人科産科77巻6号

2023年06月発行

今月の臨床 更年期症状への補完代替医療の最新知見―科学的根拠を踏まえて 補完代替医療それぞれの作用機序と効果

―【サプリメント】―エクオールの最新知見

著者： 飯野香理¹ 飯野勢² 樋口毅³ 横山良仁¹

所属機関： ¹弘前大学大学院医学研究科産科婦人科学講座 ²弘前大学大学院医学研究科消化器血液内科学講座 ³弘前大学大学院保健学研究科健康支援科学領域

ページ範囲：P.583 - P.589

●エクオールは特定の腸内細菌によって大豆イソフラボンより代謝され，エストロゲン様作用を示す．

●エクオールを産生できるかどうかは尿中のエクオール濃度を測定することで判定できるが，個々の産生能は経時的に変化することが明らかとなった．エクオール産生の変化には，エクオール産生菌の有無や大豆製品の摂取量だけでは説明できず，他の要因が関与している可能性がある．

●近年，エクオールがさまざまな疾患に対して予防的に作用する可能性が指摘されている．しかし，エクオールと疾患との関連性に関する検証はまだ十分ではなく，精度の高い検証結果の蓄積が望まれる．

参考文献

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