臨床婦人科産科77巻7号

2023年07月発行

今月の臨床 細菌叢から読み解く女性と子どものヘルスケア

リプロダクション

腸内細菌叢異常とPCOS

著者： 草本朱里¹ 原田美由紀¹

所属機関： ¹東京大学医学部附属病院女性診療科・産科

ページ範囲：P.691 - P.696

文献概要

●PCOS患者，PCOS動物モデルにおいて，腸内細菌叢の変化が示されている．

●腸内細菌叢がPCOSの病態形成に関与している可能性がある．

●腸内細菌叢の改善がPCOSの発症予防・治療につながることが期待される．

参考文献

1）Risal S, et al : Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome. Nat Med 25 : 1894-1904, 2019

2）Dunaif A : Perspectives in polycystic ovary syndrome : From hair to eternity. J Clin Endocrinol Metab 101 : 759-768, 2016

3）Harada M : Pathophysiology of polycystic ovary syndrome revisited : Current understanding and perspectives regarding future. Reprod Med Biol 21 : e12487, 2022

4）Sir-Petermann T, et al : Maternal serum androgens in pregnant women with polycystic ovarian syndrome : possible implications in prenatal androgenization. Hum Reprod 17 : 2573-2579, 2002

5）Maliqueo M, et al : Placental steroidogenesis in pregnant women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol 166 : 151-155, 2013

6）Barrett ES, et al : Anogenital distance in newborn daughters of women with polycystic ovary syndrome indicates fetal testosterone exposure. J Dev Orig Health Dis 9 : 307-314, 2018

7）Dumesic DA, et al : Mechanisms of intergenerational transmission of polycystic ovary syndrome. Reproduction 159 : R1-R13, 2020

8）Rizk MG, et al : Intersection of polycystic ovary syndrome and the gut microbiome. J Endocr Soc 5 : bvaa177, 2020

9）Guo J, et al : Gut microbiota in patients with polycystic ovary syndrome : a systematic review. Reprod Sci 29 : 69-83, 2020

10）Torres PJ, et al : Exposure to a healthy gut microbiome protects against reproductive and metabolic dysregulation in a PCOS mouse model. Endocrinology 160 : 1193-1204, 2019

11）Thackray VG : Sex, microbes, and polycystic ovary syndrome. Trends Endocrinol Metab 30 : 54-65, 2019

12）Qi X, et al : Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome. Nat Med 25 : 1225-1233, 2019

13）Caldwell ASL, et al : Characterization of reproductive, metabolic, and endocrine features of polycystic ovary syndrome in female hyperandrogenic mouse models. Endocrinology 155 : 3146- 3159, 2014

14）Kusamoto A, et al : Temporal relationship between alterations in the gut microbiome and the development of polycystic ovary syndrome-like phenotypes in prenatally androgenized female mice. FASEB J 35 : e21971, 2021