臨床婦人科産科78巻1号

2024年01月発行

合併増大号　今月の臨床 産婦人科医のための感染症最新レクチャー 各論 : 腫瘍学

HPVによる発がんのメカニズム

著者： 日下部美佐子¹² 田口歩¹³

所属機関： ¹東京大学医学部附属病院女性診療科・産科／女性外科 ²がん・感染症センター都立駒込病院婦人科 ³大阪大学免疫学フロンティア研究センター

ページ範囲：P.132 - P.138

●ヒトパピローマウイルス（HPV）発がんは多段階発がんであり，がん遺伝子E6/E7の発現，HPVインテグレーションによるE6/E7の恒常的発現，ヒト遺伝子変異の蓄積の3つのステップで発がんに至る．

●子宮頸がんの組織分化・細胞起源について新たな知見が得られてきている．

●HPVサブタイプにより，子宮頸部の感染細胞の自然史が異なる．

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