臨床婦人科産科78巻11号

2024年11月発行

今月の臨床 生殖医療の最新潮流とその一歩先

最新潮流 : 卵巣予備能から着床まで 【配偶子と授精・胚発育】

高感度AMH測定

著者： 大須賀智子¹ 伊吉祥平¹²

所属機関： ¹名古屋大学大学院医学系研究科産婦人科学 ²名古屋大学高等研究院

ページ範囲：P.970 - P.974

文献概要

●高感度AMH測定により，従来の測定法では測定感度以下となる微量な血中AMHを検出できる．

●従来法でAMHが測定感度以下のPOI症例においても，高感度AMH測定でAMH陽性の場合がある．

●高感度AMH測定がPOI症例の卵胞発育予測に役立つ．

参考文献

1）Broer SL, et al : Anti-Müllerian hormone : ovarian reserve testing and its potential clinical implications. Hum Reprod Update 20 : 688-701, 2014

2）Broekmans FJ, et al : A systematic review of tests predicting ovarian reserve and IVF outcome. Hum Reprod Update 12 : 685-718, 2006

3）ESHRE Guideline Group on Ovarian Stimulation；Bosch E, et al : ESHRE guideline : ovarian stimulation for IVF/ICSI. Hum Reprod Open 2020 : hoaa009, 2020

4）Osuka S, et al : Follicle development and its prediction in patients with primary ovarian insufficiency : possible treatments and markers to maximize the ability to conceive with residual follicles. Reprod Med Biol 22 : e12556, 2023

5）Su HI, et al : Comparability of antimüllerian hormone levels among commercially available immunoassays. Fertil Steril 101 : 1766-1772.e1, 2014

6）Decanter C, et al : Toward a better follow-up of ovarian recovery in young women after chemotherapy with a hypersensitive antimüllerian hormone assay. Fertil Steril 102 : 483-487, 2014

7）Iwase A, et al : Usefulness of the ultrasensitive anti-Müllerian hormone assay for predicting true ovarian reserve. Reprod Sci 23 : 756-760, 2016

8）Kasahara Y, et al : Very low levels of serum anti-Müllerian hormone as a possible marker for follicle growth in patients with primary ovarian insufficiency under hormone replacement therapy. Reprod Sci 28 : 31-36, 2021

9）本邦における多囊胞性卵巣症候群の診断基準の検証に関する小委員会：多囊胞性卵巣症候群の診断基準（2024）について．日産婦会誌76 : 97-100, 2024

10）FDA permits marketing of a diagnostic test to aid in the determination of menopausal status. Available from : https://www.fda.gov/news-events/press-announcements/fda-permits-marketing-diagnostic-test-aid-determination-menopausal-status