臨床婦人科産科78巻11号

2024年11月発行

今月の臨床 生殖医療の最新潮流とその一歩先

最新潮流 : 卵巣予備能から着床まで 【子宮内膜の評価と着床】

ERA検査・ERPeak検査

著者： 京野廣一¹ 笠原佑太¹ 橋本朋子¹

所属機関： ¹京野アートクリニック高輪

ページ範囲：P.1004 - P.1008

文献概要

●着床の窓 : 正倍数性胚盤胞が着床するのに最適な子宮内膜の受容期間．

●ERA : 次世代シークエンサーを用いて248遺伝子を解析し，着床に最適な着床の窓を調べる．

●ERPeak : RT-qPCRを用いて48遺伝子を解析し，着床に最適な着床の窓を調べる．

参考文献

1）Coutifaris C, et al : Reprint of : Histological dating of timed endometrial biopsy tissue is not related to fertility status. Fertil Steril 112（Suppl 1） : e116-e124, 2019

2）Ruiz-Alonso M, et al : The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure. Fertil Steril 100 : 818-824, 2013

3）京野廣一，他 : 子宮内膜着床能（endometrial receptivity analysis ; ERA）．HORM FRONT GYNECOL 29 : 120-125, 2022

4）Takeshige Y, et al : Clinical outcomes of personalized blastocyst embryo transfer after endometrial receptivity analysis : a multicenter, retrospective cohort study. Reprod Med Biol 22 : e12550, 2023

5）Ohara Y, et al : Clinical relevance of a newly developed endometrial receptivity test for patients with recurrent implantation failure in Japan. Reprod Med Biol 21 : e12444, 2022

6）Liu Z, et al : The clinical efficacy of personalized embryo transfer guided by the endometrial receptivity array/analysis on IVF/ICSI outcomes : a systemic review and meta-analysis. Front Physiol 13 : 841437, 2022

7）Mei Y, et al : Does endometrial receptivity array improve reproductive outcomes in euploid embryo transfer cycles? a systematic review. Front Endocrinol（Lausanne） 14 : 1251699, 2023

8）Hashimoto T, et al : Efficacy of the endometrial receptivity array for repeated implantation failure in Japan : a retrospective, two-centers study. Reprod Med Biol 16 : 290-296, 2017

9）Tan J, et al : The role of the endometrial receptivity array（ERA） in patients who have failed euploid embryo transfers. J Assist Reprod Genet 35 : 683-692, 2018

10）Doyle N, et al : Effect of endometrial receptivity testing vs standard timing of frozen embryo transfer on live birth in patients undergoing in vitro fertilization. JAMA 328 : 2117-2125, 2022