臨床婦人科産科78巻6号

2024年06月発行

今月の臨床 子宮頸がん撲滅へ向けた戦略―ワクチンと検診の新たなトレンドは？ HPVワクチン

2価・4価HPVワクチンの効果

著者： 橋本千明¹ 重田昌吾¹ 島田宗昭¹²

所属機関： ¹東北大学病院婦人科 ²東北大学高等研究機構未来型医療創成センター

ページ範囲：P.490 - P.494

●2価・4価HPVワクチンの有効性に関しては11〜14年程度の持続効果が報告され，長期間の有効性が示されつつある．

●HPVワクチンの子宮頸がんに対する予防効果が海外で示されてきたが，本邦においても2023年に初めて報告された．

●2022年4月よりHPVワクチンの積極的接種勧奨が再開され，今後，ワクチン接種率の回復が期待される．

参考文献

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2）Lehtinen M, et al : Overall effi cacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia : 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial. Lancet Oncol 13 : 89-99, 2012

3）Porras, C, et al : Efficacy of the bivalent HPV vaccine against HPV 16/18-associated precancer : long-term follow-up results from the Costa Rica vaccine trial. Lancet Oncol 21 : 1643-1652, 2020

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8）Ozawa N, et al : Lower incidence of cervical intraepithelial neoplasia among young women with human papillomavirus vaccination in Miyagi, Japan. Tohoku J Exp Med 243 : 329-334, 2018

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11）Falcaro M, et al : The effects of the national HPV vaccination programme in England, UK, on cervical cancer and grade 3 cervical intraepithelial neoplasia incidence : a register-based observational study. Lancet 398 : 2084-2092, 2021

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13）Nakazawa H, et al : Age at first sexual intercourse among young women with invasive cervical cancer : implications for routine vaccination against human papillomavirus in Japan. Jpn J Clin Oncol 53 : 530-533, 2023

14）Sekine M, et al : Suspension of proactive recommendations for HPV vaccination has led to a significant increase in HPV infection rates in young Japanese women : real world data. Lancet Reg Health West Pac 16 : 100300, 2021

15）Yagi A, et al : The looming health hazard : a wave of HPV-related cancers in Japan is becoming a reality due to the continued suspension of the governmental recommendation of HPV vaccine. Lancet Reg Health West Pac 18 : 100327, 2022