臨床婦人科産科78巻6号

2024年06月発行

今月の臨床 子宮頸がん撲滅へ向けた戦略―ワクチンと検診の新たなトレンドは？ 大規模疫学研究・社会医学研究

NIIGATA STUDY

著者： 黒澤めぐみ¹ 工藤梨沙¹ 関根正幸²

所属機関： ¹新潟大学医学部産科婦人科学教室 ²琉球大学大学院医学研究科女性・生殖医学講座

ページ範囲：P.519 - P.524

●NIIGATA STUDYは，新潟県のHPVワクチンの公費接種世代を含む20代女性を対象として，自治体の子宮がん検診受診者を登録し，HPV感染率，細胞診異常率，組織診異常率をワクチン接種群と非接種群とで比較する横断研究である．

●HPVワクチン接種によりHPV感染率と前がん病変発症の予防効果が確認された．

●積極的勧奨中止による影響で対象世代のHPV16/18型感染率が再上昇しており，キャッチアップ接種の推進や検診事業の強化などの施策が必要である．

参考文献

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13）Kudo R, et al : Effectiveness of human papillomavirus vaccine against cervical precancer in Japan : multivariate analyses adjusted for sexual activity. Cancer Sci 113 : 3211-3220, 2022

14）Porras C, et al : Efficacy of the bivalent HPV vaccine against HPV 16/18-associated precancer : long-term follow-up results from the Costa Rica Vaccine Trial. Lancet Oncol 21 : 1643-1652, 2020

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17）Sekine M, et al : Suspension of proactive recommendations for HPV vaccination has led to a significant increase in HPV infection rates in young Japanese women : real-world data. Lancet Reg Health West Pac 16 : 100300, 2021