臨床検査49巻13号

2005年12月発行

今月の主題 メタボリックシンドローム 総説

脂肪組織における遺伝子発現

著者： 前田和久¹ 船橋徹¹

所属機関： ¹大阪大学大学院医学系研究科内分泌・代謝内科学

ページ範囲：P.1639 - P.1647

〔SUMMARY〕　世界で最初のヒト脂肪組織遺伝子発現情報データベースは，ヒトゲノムプロジェクトにおいて構築され，2つの大きな特徴が明らかにされた．1つが分泌臓器としての脂肪組織の特性，つまりアディポサイトカインの概念であり，もう1つが同データベースよりクローニングされたアディポネクチンをはじめとする脂肪組織特異的遺伝子のもつ大きなインパクトである．本稿ではこれらアディポサイエンスの中核を担う因子とメタボリックシンドロームとのかかわり合いについて総括したい．〔臨床検査　49：1639-1647，2005〕

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