臨床検査51巻13号

2007年12月発行

今月の主題 胎盤 総説

母体の胎児に対する免疫寛容成立機序

著者： 工藤美樹¹

所属機関： ¹広島大学大学院医歯薬学総合研究科産科婦人科学

ページ範囲：P.1659 - P.1663

　同種移植片である胎児が母体の免疫系により拒絶されることなく妊娠が維持されるためには，母体において胎児に対する免疫寛容の状態が形成されていると推測されている．この胎児に対する母体の免疫寛容成立機序に関する研究は広範囲に行われており，種々の機序が推測されている．それらのひとつひとつの機序は妊娠に特異的または非特異的なものであるが，お互いが組み合わさって作用することによって免疫寛容状態を成立させていると考えられている．

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