臨床検査51巻5号

2007年05月発行

今月の主題 脂質 脂質関連物質の作用機序

核内受容体を介した脂性生理活性物質の作用機序

著者： 加藤茂明¹

所属機関： ¹東京大学分子細胞生物学研究所

ページ範囲：P.469 - P.475

　性ステロイドホルモンをはじめとした低分子量脂溶性生理活性物質群をリガンドとする核内受容体群は，リガンド依存性DNA結合性転写制御因子として機能し，標的遺伝子群の発現を転写レベルで制御する．その結果発現制御される遺伝子産物が，これらリガンドの生理作用を担う．本稿では，この転写制御を，最近明らかにされつつある核内受容体と相互作用する転写共役因子複合体群の機能を中心に概観したい．これら複合体の本質的機能は，転写制御に伴う染色体構造調節・ヒストン修飾を行う本体であることが明らかにされつつあり^1,2)，核内受容体による染色体構造調節と転写制御の分子機構を紹介する．〔臨床検査　51：469-475，2007〕

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