臨床検査52巻13号

2008年12月発行

今月の主題 凝固制御 総論

遺伝子改変動物に学ぶ血液凝固制御

著者： 岩永貞昭¹ 中垣智弘¹ 水口純²

所属機関： ¹財団法人化学及血清療法研究所(化血研)蛋白製剤研究部 ²財団法人化学及血清療法研究所(化血研)企画部

ページ範囲：P.1523 - P.1531

　血液凝固の制御機構を分類すると，①プロテインC系による，凝固コファクター(VとVIII因子)の特異的分解と不活性化，②プロテアーゼインヒビター系による凝固プロテアーゼの活性阻害と複合体形成に大別される．②のインヒビター系は，セルピン型(アンチトロンビンやヘパリンコファクターⅡ，プロテインZ-セルピン複合体など)や外因系凝固インヒビターなどが知られている．本稿では，これらの制御系を構成する諸因子について，それらの遺伝子改変動物から得られた知見を中心に概説する．

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