臨床検査52巻6号

2008年06月発行

今月の主題 エピジェネティクスと臨床検査 臨床検査への展開

網羅的エピゲノム解析技術

著者： 油谷浩幸¹

所属機関： ¹東京大学先端科学技術研究センター

ページ範囲：P.643 - P.648

　ヒストン修飾やDNAメチル化は，染色体からの遺伝子発現を調節する重要なエピジェネティック修飾であり，マイクロアレイや高速シークエンサーを用いたハイスループットなゲノム解析技術がその網羅的解析を可能にした．今後，疾患マーカーのみならず，ヒストン脱アセチル化酵素阻害剤や脱メチル化剤などのエピジェネティック医薬の臨床開発において，症例の層別化に利用可能なエピゲノム情報に基づくバイオマーカーとしての開発も期待される．

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