臨床検査52巻8号

2008年08月発行

今月の主題 自然免疫と生体防御レクチン 総説

マンノース結合レクチン(MBL)とフィコリン(ficolin)の構造と機能

著者： 遠藤雄一¹ 松下操² 藤田禎三¹

所属機関： ¹福島県立医科大学医学部免疫学 ²東海大学工学部生命科学

ページ範囲：P.841 - P.850

　MBLとフィコリンは，N末端側にコラーゲン様ドメインをもつ多価レクチンであり，自然免疫において感染微生物などの表面糖鎖を認識する．MBLとフィコリンの糖認識は，それぞれC末端側に存在するCRD(糖鎖認識ドメイン)およびフィブリノーゲン様ドメインが担っている．MBLとフィコリンによるパターン認識は，両者と複合体を形成しているセリンプロテアーゼMASPを活性型にし補体系を活性化する．この経路は補体レクチン経路と呼ばれる．

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