臨床検査52巻8号

2008年08月発行

今月の主題 自然免疫と生体防御レクチン 総説

ガレクチンと免疫調節

著者： 中村隆範¹ 西望² 東海林博樹³

所属機関： ¹香川大学医学部分子細胞機能学 ²香川大学総合生命科学研究センター ³香川大学分子細胞機能学

ページ範囲：P.871 - P.879

　ガレクチンはすべての脊椎動物に存在して，グラム陰性菌リポ多糖(LPS)など病原体を認識して感染菌を排除する機能ももつが，基本的には自己がもつ糖蛋白質や糖脂質の糖鎖を認識する糖結合蛋白質(レクチン)に属する．最近，ガレクチンは自然免疫細胞(顆粒球，マクロファージ，肥満細胞)などに直接作用して自然免疫機能を高めるとともに，T細胞の分化や機能調節を通じて獲得免疫機能に関与することがわかってきた．

参考文献

1) Barondes SH, Castronovo V, Cooper DN, et al：Galectins：a family of animal beta-galactoside-binding lectins. Cell　76：597-598, 1994

2) Rabinovich GA, Liu FT, Hirashima M, et al：An emerging role for galectins in tuning the immune response：lessons from experimental models of inflammatory disease, autoimmunity and cancer. Scand J Immunol　66：143-158, 2007

3) Sato S, Nieminen J：Seeing strangers or announcing "danger"：galectin-3 in two models of innate immunity. Glycoconj J　19：583-591, 2004

4) Pace KE, Hahn HP, Pang M, et al：CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death. J Immunol　165：2331-2334, 2000

5) Kashio Y, Nakamura K, Abedin MJ, et al：Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway. J Immunol　170：3631-3636, 2003

6) Lu LH, Nakagawa R, Kashio Y, et al：Characterization of galectin-9-induced death of Jurkat T cells. J Biochem　141：157-172, 2007

7) Hirabayashi J, Hashidate T, Arata Y, et al：Oligosaccharide specificity of galectins：a search by frontal affinity chromatography. Biochim Biophys Acta　1572：232-254, 2002

8) 久保允人：T細胞サブセット　分化のメカニズムと免疫疾患の制御．細胞工学　27：110-113, 2008

9) Zhu C, Anderson AC, Schubart A, et al：The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol　6：1245-1252, 2005

10) Anderson AC, Anderson DE, Bregoli L, et al：Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science　318：1141-1143, 2007

11) Seki M, Oomizu S, Sakata KM, et al：Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin Immunol　127：78-88, 2008

12) Elola MT, Wolfenstein-Todel C, Troncoso MF, et al：Galectins：matricellular glycan-binding proteins linking cell adhesion, migration, and survival. Cell Mol Life Sci　64：1679-1700, 2007

13) Nishi N, Shoji H, Seki M, et al：Galectin-8 modulates neutrophil function via interaction with integrin alphaM. Glycobiology　13：755-763, 2003

14) Yamamoto H, Nishi N, Shoji H, et al：Induction of cell adhesion by galectin-8 and its target molecules in Jurkat T-cells. J Biochem　143：311-324, 2008

15) Rabinovich GA, Toscano MA, Jackson SS, et al：Functions of cell surface galectin-glycoprotein lattices. Curr Opin Struct Biol　17：513-520, 2007

16) Lau KS, Partridge EA, Grigorian A, et al：Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. Cell　129：123-134, 2007

17) Pelletier I, Hashidate T, Urashima T, et al：Specific recognition of Leishmania major poly-beta-galactosyl epitopes by galectin-9：possible implication of galectin-9 in interaction between L. major and host cells. J Biol Chem　278：22223-22230, 2003

18) Liu FT, Rabinovich GA：Galectins as modulators of tumour progression. Nat Rev Cancer　5：29-41, 2005

19) Irie A, Yamauchi A, Kontani K, et al：Galectin-9 as a prognostic factor with antimetastatic potential in breast cancer. Clin Cancer Res　11：2962-2968, 2005