臨床検査52巻8号

2008年08月発行

今月の主題 自然免疫と生体防御レクチン 各論

細菌に対する感染防御におけるフィコリンの役割

著者： 高橋信二¹ 青柳祐子¹

所属機関： ¹女子栄養大学微生物学研究室

ページ範囲：P.887 - P.892

　フィコリン-MASP複合体は，抗体の関与なしに補体系を活性化するレクチン経路の異物認識分子である．L-ficolinとH-ficolinは血液中に認められ，M-ficolinは好中球や単球の分泌蛋白質である．L-ficolinは試験管内で，臨床上重要なStaphylococcus aureusやStreptococcus agalactiaeに結合し補体系を活性化することができる．フィコリンは，特に獲得免疫が不完全な新生児や乳児において感染防御に重要な役割を担っている可能性が示唆されている．

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