臨床検査52巻8号

2008年08月発行

今月の主題 自然免疫と生体防御レクチン 各論

炎症におけるpentraxin3の役割

著者： 奥谷大介¹

所属機関： ¹独立行政法人国立病院機構南岡山医療センター外科

ページ範囲：P.905 - P.910

　pentraxin(PTX)3は同じ仲間であるC反応性蛋白質(CRP)と同様に免疫や炎症において重要である．PTX3は炎症に反応して，血管内皮細胞やマクロファージなどの全身の細胞より産生されるため，肝臓のみで産生されるCRPと異なり，局所的な感染や炎症に敏感に反応する．正常な状態では，血液中のPTX3レベルは極めて低いが，炎症が起こるとそのレベルは急激に上昇する．臨床においてPTX3の血清レベルが特定の炎症性疾患の重症度，治療や予後などと相関すると報告されている．

参考文献

1) Emsley J, White HE, O'Hara BP, et al：Structure of pentameric human serum amyloid P component. Nature　367：338-345, 1994

2) Luchetti MM, Piccinini G, Mantovani A, et al：Expression and production of the long pentraxin PTX3 in rheumatoid arthritis(RA). Clin Exp Immunol　119：196-202, 2000

3) Bussolati B, Peri G, Salvidio G, et al：The long pentraxin PTX3 is synthesized in IgA glomerulonephritis and activates mesangial cells. J Immunol　170：1466-1472, 2003

4) Garlanda C, Hirsch E, Bozza S, et al：Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature　420：182-186, 2002

5) Muller B, Peri G, Doni A, et al：Circulating levels of the long pentraxin PTX3 correlate with severity of infection in critically ill patients. Crit Care Med　29：1404-1407, 2001

6) Pepys MB, Hirschfield GM：C-reactive protein：a critical update. J Clin Invest　111：1805-1812, 2003

7) Pepys MB, Baltz ML：Acute phase proteins with special reference to C-reactive protein and related proteins(pentaxins)and serum amyloid A protein. Adv Immunol　34：141-212, 1983

8) Mantovani A, Garlanda C, Bottazzi B：Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity. Vaccine 21 Suppl　2：S43-47, 2003

9) He X, Han B, Liu M：Long pentraxin 3 in pulmonary infection and acute lung injury. Am J Physiol Lung Cell Mol Physiol　292：L1039-L1049, 2007

10) Breviario F, d'Aniello EM, Golay J, et al：Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component. J Biol Chem　267：22190-22197, 1992

11) Lee GW, Lee TH, Vilcek J：TSG-14, a tumor necrosis factor-and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. J Immunol　150：1804-1812, 1993

12) Abderrahim-Ferkoune A, Bezy O, Chiellini C, et al：Characterization of the long pentraxin PTX3 as a TNFalpha-induced secreted protein of adipose cells. J Lipid Res　44：994-1000, 2003

13) Han B, Mura M, Andrade CF, et al：TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK. J Immunol　175：8303-8311, 2005

14) Nauta AJ, de Haij S, Bottazzi B, et al：Human renal epithelial cells produce the long pentraxin PTX3. Kidney Int　67：543-553, 2005

15) Gewurz H, Zhang XH, Lint TF：Structure and function of the pentraxins. Curr Opin Immunol　7：54-64, 1995

16) Basile A, Sica A, d'Aniello E, et al：Characterization of the promoter for the human long pentraxin PTX3. Role of NF-kappaB in tumor necrosis factor-alpha and interleukin-1beta regulation. J Biol Chem　272：8172-8178, 1997

17) Altmeyer A, Klampfer L, Goodman AR, et al：Promoter structure and transcriptional activation of the murine TSG-14 gene encoding a tumor necrosis factor/interleukin-1-inducible pentraxin protein. J Biol Chem　270：25584-25590, 1995

18) Alles VV, Bottazzi B, Peri G, et al：Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes. Blood　84：3483-3493, 1994

19) Doni A, Peri G, Chieppa M, et al：Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells. Eur J Immunol　33：2886-2893, 2003

20) Klouche M, Peri G, Knabbe C, et al：Modified atherogenic lipoproteins induce expression of pentraxin-3 by human vascular smooth muscle cells. Atherosclerosis　175：221-228, 2004

21) Rolph MS, Zimmer S, Bottazzi B, et al：Production of the long pentraxin PTX3 in advanced atherosclerotic plaques. Arterioscler Thromb Vasc Biol　22：e10-e14, 2002

22) 井上健司：新規血管炎症マーカー，pentraxin3．医学のあゆみ　224：353-358，2008

23) Latini R, Maggioni AP, Peri G, et al：Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction. Circulation　110：2349-2354, 2004

24) Salio M, Chimenti S, De Angelis N, et al：Cardioprotective function of the long pentraxin PTX3 in acute myocardial infarction. Circulation.　117：1055-64, 2008

25) Okutani D, Han B, Mura M, et al：High-volume ventilation induces pentraxin 3 expression in multiple acute lung injury models in rats. Am J Physiol Lung Cell Mol Physiol　292：L144-153, 2007

26) Gaziano R, Bozza S, Bellocchio S, et al：Combination therapy with pentraxin 3 and antifungals in experimentalaspergillosis. Antimicrob agents chemother　48：4414-4421, 2004

27) Garlanda C, Bottazzi B, Bastone A, et al：Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility. Annu Rev Immunol　23：337-366, 2005

28) Dias AA, Goodman AR, Dos Santos JL, et al：TSG-14 transgenic mice have improved survival to endotoxemia and to CLP-induced sepsis. J Leukoc Biol　69：928-936, 2001

29) Mairuhu AT, Peri G, Setiati TE, et al：Elevated plasma levels of the long pentraxin, pentraxin 3, in severe dengue virus infections. J Med Virol　76：547-552, 2005