臨床検査53巻12号

2009年11月発行

今月の主題 オートファジー 総論

オートファジーの分子機構

著者： 岸千絵子¹ 板倉英祐¹ 水島昇¹

所属機関： ¹東京医科歯科大学大学院医歯学総合研究科細胞生理学分野

ページ範囲：P.1519 - P.1525

　オートファジーとは，二重膜構造体であるオートファゴソームが細胞質の一部またはオルガネラを囲み，続いてリソソームと融合することでその内容物を分解する系である．この分解は主として非選択的であり，栄養飢餓などにより顕著に誘導される．オートファゴソームの膜形成はダイナミックな膜変化を伴うユニークな現象である．酵母を用いた遺伝学的解析から，その詳しい分子機構が明らかにされつつある．本稿では最近の哺乳類における知見を中心にオートファジーの分子機構について紹介する．

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