臨床検査53巻5号

2009年05月発行

今月の主題 免疫不全症候群と遺伝子異常 免疫不全症の臨床検査

免疫不全症のFACSによる簡易診断法

著者： 金兼弘和¹ 堺千賀子¹ 宮脇利男¹

所属機関： ¹富山大学医学部小児科

ページ範囲：P.541 - P.546

　免疫不全症は生体の免疫系を維持するうえで必要な免疫担当分子の先天的欠陥によって生じる．障害部位によって分類され，150種類以上からなる雑多な症候群であるが，120種類以上で責任遺伝子が同定されており，遺伝子診断による確定診断が可能である．しかし遺伝子解析には時間と労力を要する．利用可能なモノクローナル抗体があればFACSによる簡易診断が可能な疾患がいくつかあり，本稿では免疫不全症におけるFACSによる簡易診断法について紹介したい．

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