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臨床検査54巻2号

2010年02月発行

文献概要

今月の主題 の診断と臨床応用 総論

Helicobacter pyloriの基礎知識

著者: 前田愼1

所属機関: 1東京大学附属病院消化器内科

ページ範囲:P.133 - P.140

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 Helicobacter pyloriは1983年に発見されたグラム陰性桿菌である.高齢者の60%以上が保菌者であるが,若年者の感染率は次第に低下している.診断は迅速ウレアーゼ試験・鏡検法・培養法・尿素呼気試験・血清抗体測定法などで行う.わが国では胃・十二指腸潰瘍(または瘢痕)に対してプロトンポンプ阻害剤(PPI)+アモキシシリン(AMPC)+クラリスロマイシン(CAM)による一次除菌療法,PPI+AMPC+メトロニダゾール(MNZ)による二次除菌療法が保険適用である.病原因子としてBabAやSabAなどの接着因子,CagA/cagPAIやVacAなどの細胞障害因子があり,その存在や変異による疾患への関与が示唆されている.

参考文献

1) Freedberg AS, Barron LE:The presence of spirochetes in human gastric muc. Am J Dig Dis 7:443-445, 1940
2) Palmer ED:Investigation of the gastric mucosa spirochetes of the human. Gastroenterology 27:218-220, 1954
3) Marshall BJ, Warren JR:Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1:1311-1315, 1984
4) Marshall BJ, Armstrong JA, McGechie DB, et al:Attempt to fulfil Koch's postulates for pyloric Campylobacter. Med J Aust 142:436-439, 1985
causes gastritis and raised fasting gastric pH. Am J Gastroenterol 82:192-199, 1987
infection in Mongolian gerbils. J Gastroenterol 31 Suppl 9:24-28, 1996
infection induces gastric cancer in mongolian gerbils. Gastroenterology 115:642-648, 1998
to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology 102:760-766, 1992
infection and the development of gastric cancer. N Engl J Med 345:784-789, 2001
on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer:an open-label, randomised controlled trial. Lancet 372:392-397, 2008
. Nature 388:539-547, 1997
ABO blood group antigen binding adhesin. Science 305:519-522, 2004
SabA adhesin in persistent infection and chronic inflammation. Science 297:573-578, 2002
sabA genotype in Japanese clinical isolates. J Gastroenterol Hepatol 22:2228-2232, 2007
. Gastroenterology 128:833-848, 2005
. Proc Natl Acad Sci USA 97:7533-7538, 2000
virulence and genetic geography. Science 284:1328-1333, 1999
CagA protein can be tyrosine phosphorylated in gastric epithelial cells. J Exp Med 191:593-602, 2000
CagA protein. Science 295:683-686, 2002
CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature 447:330-333, 2007
21) Shibata W, Hirata Y, Maeda S, et al:CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil model. J Pathol 210:306-314, 2006
-induced interleukin-8 production by a gastric cancer cell line, MKN45. Infect Immun 65:3218-3224, 1997
responsible for gastric diseases in Mongolian gerbil. J Exp Med 192:1601-1610, 2000
induced transactivation of SRE and AP-1 through the ERK signalling pathway in gastric cancer cells. Gut 49:18-22, 2001
activates the cyclin D1 gene through mitogen-activated protein kinase pathway in gastric cancer cells. Infect Immun 69:3965-3971, 2001
. Gastroenterology 112:92-99, 1997
vacuolating cytotoxin inhibits T lymphocyte activation. Science 301:1099-1102, 2003
water-soluble proteins upregulates chemokine expression in human eosinophils via Ca2+ influx, mitochondrial reactive oxygen intermediates, and NF-kappaB activation. Infect Immun 75:3373-3381, 2007

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1367

印刷版ISSN:0485-1420

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